ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2021
Reward-Related Neural Predictors and Mechanisms of Symptom Change in Cognitive Behavioral Therapy for Depressed Adolescent Girls.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Examining the relationship between pre-treatment anhedonia and treatment outcomes in individuals with anxiety or depression: A systematic review.Journal of affective disorders · 2026Pooled it
- Neural responsiveness to reward and suicidal ideation in social anxiety and major depression before and after psychotherapy.Biological psychology · 2023Trial
- Resting-state functional connectivity of the default mode network as a predictor for escitalopram response in adolescents with depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Brain rhythms of depression: A predictive processing perspective.Trends in neurosciences · 2026Review
- Suicide attempt history is associated with blunted neural reward responsiveness after accounting for a history of suicidal ideation and preparatory behaviors.Cognitive, affective & behavioral neuroscience · 2026Article
- Adverse childhood experiences and internalizing symptoms: the moderating role of neural responses to threat.Neurobiology of stress · 2025Article
- Probing Neurophysiological Processes Related to Self-Referential Processing to Predict Improvement in Adolescents With Depression Receiving Cognitive Behavioral Therapy.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Dynamic processes in behavioral activation therapy for anhedonic adolescents: Modeling common and patient-specific relations.Journal of consulting and clinical psychology · 2024Article
- Biomarkers associated with treatment outcome in young people with depression: A systematic review.Neuroscience applied · 2024Review
- Characterizing positive and negative valence systems function in adolescent depression: An RDoC-informed approach integrating multiple neural measures.Journal of mood and anxiety disorders · 2023Article
- Neural Predictors of Improvement With Cognitive Behavioral Therapy for Adolescents With Depression: An Examination of Reward Responsiveness and Emotion Regulation.Research on child and adolescent psychopathology · 2023Article
- Identifying Transdiagnostic Mechanisms in Mental Health Using Computational Factor Modeling.Biological psychiatry · 2023Review
- Reward-related predictors of symptom change in behavioral activation therapy for anhedonic adolescents: a multimodal approach.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Anhedonia in Depression and Bipolar Disorder.Current topics in behavioral neurosciences · 2022Article
- P300 amplitude during a monetary incentive delay task predicts future therapy completion in individuals with major depressive disorder.Journal of affective disorders · 2021Article
- Neurophysiological predictors of gaze-contingent music reward therapy among adults with social anxiety disorder.Journal of psychiatric research · 2021Article
- Depressive rumination is correlated with brain responses during self-related processing.Journal of psychiatry & neuroscience : JPN · 2021Article
- Predictors of Treatment Outcome in Adolescent Depression.Current treatment options in psychiatry · 2021Article
Corrections and comments
- Commented on by
- Erratum issuedErratum.2023
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundApproximately half of depressed adolescents fail to respond to cognitive behavioral therapy (CBT). Given the variability in response, it is important to identify pretreatment characteristics that predict prognosis. Knowledge of which depressed adolescents are likely to exhibit a positive versus poor outcome to CBT may have important clinical implications (e.g., informing treatment recommendations). Emerging evidence suggests that neural reward responsiveness represents one promising predictor.
methodsAdolescents with major depressive disorder (n = 36) received CBT and completed a reward task at 3 time points (pretreatment, midtreatment and posttreatment) while 128-channel electroencephalographic data were acquired. Healthy control participants (n = 29) completed the same task at 3 corresponding time points. Analyses focused on event-related potentials linked to 2 stages of neural processing: initial response to rewards (reward positivity) and later, elaborative processing (late positive potential). Moreover, time-frequency analyses decomposed the reward positivity into 2 constituent components: reward-related delta and loss-related theta activity.
resultsMultilevel modeling revealed that greater pretreatment reward responsiveness, as measured by the late positive potential to rewards, predicted greater depressive symptom change. In addition, a group × condition × time interaction emerged for theta activity to losses, reflecting normalization of theta power in the group with major depressive disorder from baseline to posttreatment.
conclusionsAn event-related potential measure of sustained (late positive potential)-but not initial (reward positivity)-reward responsiveness predicted symptom improvement, which may help inform which depressed adolescents are most likely to benefit from CBT. In addition to alleviating depression, successful CBT may attenuate underlying neural (theta) hypersensitivity to negative outcomes in depressed youths.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.