Evidence map›Paper›PMID 32948286›Full record

ArticleBiochemical and biophysical research communications2020

Pathogenic mutations perturb calmodulin regulation of Na

Liang Hong, Meihong Zhang, Arvind Sridhar, Dawood Darbar

Open access · greenAbstract read
In one paragraph

Article in Biochemical and biophysical research communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Ion channel mutations and cancer.Biochemistry and biophysics reports · 2025
    Review
  4. A novel gain-of-function mutationAmerican journal of cardiovascular disease · 2025
    Article
  5. Ion Channels in the Immune Response of Asthma.Journal of respiratory biology and translational medicine · 2024
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Calmodulin Interactions with Voltage-Gated Sodium Channels.International journal of molecular sciences · 2021
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Liang HongDepartment of Medicine, University of Illinois at Chicago, Chicago, IL, USA. Electronic address: hong2004@uic.edu.
Meihong ZhangDepartment of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Arvind SridharDepartment of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Dawood DarbarDepartment of Medicine, University of Illinois at Chicago, Chicago, IL, USA; Department of Pharmacology, University of Illinois at Chicago, Chicago, IL, USA; Jesse Brown Veterans Administration, Chicago, IL, USA. Electronic address: darbar@uic.edu.
University of Illinois Chicago · US

Funding

Human iPSC-derived atrial cardiomyocytes to model atrial fibrillation in a dishR01HL150586 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DARBAR, DAWOOD, KHETANI, SALMAN R · 2020 to 2023
$2.6M
Deciphering the genetic mechanisms of atrial fibrillationR01HL138737 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DARBAR, DAWOOD · 2017 to 2020
$2.6M
Training Program in Personalized Cardiovascular Medicine (TPIPCVM)T32HL139439 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DARBAR, DAWOOD · 2018 to 2022
$2.1M
NHLBI NIH HHS R01 HL138737NHLBI NIH HHS R01 HL150586NHLBI NIH HHS T32 HL139439
6 · The paper itself

Abstract

The voltage-gated sodium channels play a key role in the generation and propagation of the cardiac action potential. Emerging data indicate that the Na

Indexed as

Point MutationAmino Acid SequenceAnimalsAtrial FibrillationBrugada SyndromeCalmodulinCell LineHumansMiceNAV1.8 Voltage-Gated Sodium ChannelProtein BindingProtein Interaction Domains and MotifsRatsCalmodulinNAV1.8 Voltage-Gated Sodium ChannelSCN10A protein, humanArrhythmiaCalmodulinNa(v)1.8Voltage-gated sodium channel

Identifiers

PMID32948286
PMCPMC11038804
OpenAlexW3087575177

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.