Evidence map›Paper›PMID 32948210›Full record

ArticleCell communication and signaling : CCS2020

Thrombospondin-1/CD47 signaling modulates transmembrane cation conductance, survival, and deformability of human red blood cells.

Rosi Bissinger, Polina Petkova-Kirova, Olga Mykhailova, Per-Arne Oldenborg, Elena Novikova, David A Donkor, Thomas Dietz, Abdulla Al Mamun Bhuyan, William P Sheffield, Marijke Grau and 4 more

Open access · goldAbstract read
In one paragraph

Article in Cell communication and signaling : CCS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. [Aloe-emodin inhibits scar tissue fibrosis through thrombospondin-1-PI3k-Akt pathway].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2025
    Article
  7. Review
  8. Review
  9. Tolerating CD47.Clinical and translational medicine · 2024
    Review
  10. Article
  11. Pathophysiology of Red Blood Cell Dysfunction in Diabetes and Its Complications.Pathophysiology : the official journal of the International Society for Pathophysiology · 2023
    Review
  12. Usnic Acid andAntioxidants (Basel, Switzerland) · 2021
    Article
  13. Article
  14. Article
  15. Thrombospondin-1 CD47 Signalling: From Mechanisms to Medicine.International journal of molecular sciences · 2021
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 4 countries.

Rosi BissingerDepartment of Internal Medicine, Division of Endocrinology, Diabetology, and Nephrology, Universitätsklinikum Tübingen, Tübingen, Germany.
Polina Petkova-KirovaInstitute of Neurobiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Olga MykhailovaCentre for Innovation, Canadian Blood Services, Edmonton, AB, Canada.
Per-Arne OldenborgDepartment of Integrative Medical Biology, Umeå University, Umeå, Sweden.
Elena NovikovaDepartment of Integrative Medical Biology, Umeå University, Umeå, Sweden.
David A DonkorCentre for Innovation, Canadian Blood Services, Hamilton, ON, Canada.
Thomas DietzInstitute of Molecular and Cellular Sports Medicine, German Sport University of Cologne, Köln, Germany.
Abdulla Al Mamun BhuyanDepartment of Physiology, Eberhard-Karls University, Tübingen, Germany.
William P SheffieldCentre for Innovation, Canadian Blood Services, Hamilton, ON, Canada.
Marijke GrauInstitute of Molecular and Cellular Sports Medicine, German Sport University of Cologne, Köln, Germany.
Ferruh ArtuncDepartment of Internal Medicine, Division of Endocrinology, Diabetology, and Nephrology, Universitätsklinikum Tübingen, Tübingen, Germany.
Lars KaestnerTheoretical Medicine and Biosciences, Saarland University, Homburg, Germany.
Jason P AckerCentre for Innovation, Canadian Blood Services, Edmonton, AB, Canada.
Syed M QadriCentre for Innovation, Canadian Blood Services, Hamilton, ON, Canada. syedm.qadri@ontariotechu.ca.ORCID 0000-0002-2193-932X
Canadian Blood Services · CAGerman Sport University Cologne · DEUmeå University · SEUniversitätsklinikum Tübingen · DEUniversity of Alberta · CABulgarian Academy of Sciences · BGOntario Tech University · CASaarland University · DEUniversity of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThrombospondin-1 (TSP-1), a Ca

methodsWhole-cell patch-clamp was employed to examine transmembrane cation conductance. RBC intracellular Ca

resultsExposure of RBCs to recombinant human TSP-1 significantly increased RBC intracellular Ca

conclusionsTaken together, our data unravel a new role for TSP-1/CD47 signaling in mediating Ca

Indexed as

Erythrocyte DeformabilitySignal TransductionCalciumCations, DivalentCD47 AntigenCell SurvivalErythrocyte MembraneErythrocytesHumansThrombospondin 1CalciumCations, DivalentCD47 AntigenCD47 protein, humanThrombospondin 1thrombospondin-1, humanCalciumCation channelsCD47DeformabilityRed blood cellsThrombospondin-1

Identifiers

PMID32948210
PMCPMC7502024
OpenAlexW3087590781

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.