Evidence map›Paper›PMID 32947921›Full record

ArticleInternational journal of molecular sciences2020

Design, Synthesis and Biological Evaluation of Biphenylglyoxamide-Based Small Molecular Antimicrobial Peptide Mimics as Antibacterial Agents.

Tsz Tin Yu, Rajesh Kuppusamy, Muhammad Yasir, Md Musfizur Hassan, Amani Alghalayini, Satyanarayana Gadde, Evelyne Deplazes, Charles Cranfield, Mark D P Willcox, David StC Black and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 20 citations in OpenAlex.

  1. Palladium-supported FeScientific reports · 2025
    Article
  2. Article
  3. Review
  4. Review
  5. Cholic Acid-Based Antimicrobial Peptide Mimics as Antibacterial Agents.International journal of molecular sciences · 2022
    Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Tsz Tin YuSchool of Chemistry, The University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0002-8484-7342
Rajesh KuppusamySchool of Chemistry, The University of New South Wales, Sydney, NSW 2052, Australia.
Muhammad YasirSchool of Optometry and Vision Science, University of New South Wales, Sydney, NSW 2052, Australia.
Md Musfizur HassanSchool of Chemistry, The University of New South Wales, Sydney, NSW 2052, Australia.
Amani AlghalayiniSchool of Life Sciences, University of Technology Sydney, PO Box 123, Ultimo 2007, Australia.ORCID 0000-0002-2308-0256
Satyanarayana GaddeSchool of Chemistry, The University of New South Wales, Sydney, NSW 2052, Australia.
Evelyne DeplazesSchool of Life Sciences, University of Technology Sydney, PO Box 123, Ultimo 2007, Australia.ORCID 0000-0003-2052-5536
Charles CranfieldSchool of Life Sciences, University of Technology Sydney, PO Box 123, Ultimo 2007, Australia.ORCID 0000-0003-3608-5440
Mark D P WillcoxSchool of Optometry and Vision Science, University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0003-3842-7563
David StC BlackSchool of Chemistry, The University of New South Wales, Sydney, NSW 2052, Australia.ORCID 0000-0001-9300-4737
Naresh KumarSchool of Chemistry, The University of New South Wales, Sydney, NSW 2052, Australia.
UNSW Sydney · AUUniversity of Technology Sydney · AU

Funding

Australian Research Council DP180100845
6 · The paper itself

Abstract

There has been an increasing interest in the development of antimicrobial peptides (AMPs) and their synthetic mimics as a novel class of antibiotics to overcome the rapid emergence of antibiotic resistance. Recently, phenylglyoxamide-based small molecular AMP mimics have been identified as potential leads to treat bacterial infections. In this study, a new series of biphenylglyoxamide-based small molecular AMP mimics were synthesised from the ring-opening reaction of

Indexed as

Anti-Bacterial AgentsAntimicrobial Cationic PeptidesBiofilmsBiphenyl CompoundsCell LineDrug DesignEscherichia coliFibroblastsHumansLipid BilayersMembrane PotentialsMicrobial Sensitivity TestsMolecular StructurePeptidomimeticsStaphylococcus aureusStructure-Activity RelationshipAnti-Bacterial AgentsAntimicrobial Cationic PeptidesbiphenylBiphenyl CompoundsglyoxamideLipid BilayersPeptidomimeticsSulfonylurea Compounds5-phenylisatinantibiofilmantimicrobial peptide mimicsbiphenylglyoxamideguanidinium hydrochloridemembrane disruptionquaternary ammonium iodide

Identifiers

PMID32947921
PMCPMC7555970
OpenAlexW3086991624

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.