Evidence map›Paper›PMID 32947803›Full record

ArticleTropical medicine and infectious disease2020

COVID-19-Induced Thrombosis in Patients without Gastrointestinal Symptoms and Elevated Fecal Calprotectin: Hypothesis Regarding Mechanism of Intestinal Damage Associated with COVID-19.

Mauro Giuffrè, Stefano Di Bella, Gianluca Sambataro, Verena Zerbato, Marco Cavallaro, Alessandro Agostino Occhipinti, Andrea Palermo, Anna Crescenti, Fabio Monica, Roberto Luzzati and 1 more

Abstract read
In one paragraph

Article in Tropical medicine and infectious disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Low transferrin levels predict heightened inflammation in patients with COVID-19: New insights.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022
    Article
  8. Review
  9. COVID-19: Current Challenges and Future Perspectives.Tropical medicine and infectious disease · 2022
    Article
  10. Acute Gastrointestinal Injury and Feeding Intolerance as Prognostic Factors in Critically Ill COVID-19 Patients.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2022
    Article
  11. Acute Mesenteric Ischemia in COVID-19 Patients.Journal of clinical medicine · 2021
    Review
  12. The Impact of COVID-19 in Gastroenterology and Hepatology.Journal of clinical gastroenterology · 2021
    Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mauro GiuffrèDepartment of Medical, Surgical and Health Sciences, University of Trieste, 34151 Trieste, Italy.ORCID 0000-0002-9910-3514
Stefano Di BellaDepartment of Medical, Surgical and Health Sciences, University of Trieste, 34151 Trieste, Italy.ORCID 0000-0001-6121-7009
Gianluca SambataroUniversity Hospital "Policlinico-Vittorio Emanuele", Department of Clinical and Experimental Medicine, University of Catania, 95100 Catania, Italy.ORCID 0000-0001-9933-1202
Verena ZerbatoInfectious Diseases Department, Udine University, 33100 Udine, Italy.
Marco CavallaroDepartment of Radiology, Trieste University Hospital, 34139 Trieste, Italy.
Alessandro Agostino OcchipintiEmergency Department, Trieste University Hospital, 34139 Trieste, Italy.
Andrea PalermoUnit of Endocrinology and Diabetes, Campus Bio-Medico University, 00128 Rome, Italy.ORCID 0000-0002-1143-4926
Anna CrescentiSection of Pathology, Campus Bio-Medico University, 00128 Rome, Italy.
Fabio MonicaDepartment of Gastroenterology, Trieste University Hospital, 34139 Trieste, Italy.
Roberto LuzzatiDepartment of Medical, Surgical and Health Sciences, University of Trieste, 34151 Trieste, Italy.
Lory Saveria CrocèDepartment of Medical, Surgical and Health Sciences, University of Trieste, 34151 Trieste, Italy.ORCID 0000-0001-9890-7011

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with coronavirus infectious disease 2019 (COVID-19) and gastrointestinal symptoms showed increased values of fecal calprotectin (FC). Additionally, bowel abnormalities were a common finding during abdominal imaging of individuals with COVID-19 despite being asymptomatic. The current pilot study aims at evaluating FC concentrations in patients without gastrointestinal symptoms.

methodswe enrolled 25 consecutive inpatients with COVID-19 pneumonia, who were admitted without gastrointestinal symptoms and a previous history of inflammatory bowel disease.

resultsAt admission, 21 patients showed increased FC with median values of 116 (87.5; 243.5) mg/kg despite absent gastrointestinal symptoms. We found a strong positive correlation between FC and D-Dimer (r = 0.745,

conclusionour findings may change the current understanding of COVID-19 intestinal-related disease pathogenesis, shedding new light on the potential role of thrombosis and the consequent hypoxic intestinal damage.

Indexed as

bowel perforationCOVID-19D-Dimerfecal calprotectinischemiaSARS-CoV-2thrombosis

Identifiers

PMID32947803
PMCPMC7557761

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.