Evidence map›Paper›PMID 32947199›Full record

ArticleAtherosclerosis2020

Association of human immunodeficiency virus and hepatitis C virus infection with long-term outcomes post-ST segment elevation myocardial infarction in a disadvantaged urban community.

Sanyog G Shitole, Mark H Kuniholm, David B Hanna, Thomas Boucher, Angel Y Peng, Cecilia Berardi, Tina Shah, Anna E Bortnick, Panagiota Christia, James Scheuer and 1 more

Open access · greenAbstract read
In one paragraph

Article in Atherosclerosis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Sanyog G ShitoleUniversity of California San Francisco and San Francisco Veterans Affairs Health Care System, 4150 Clement Street, San Francisco, CA, 94121, USA. Electronic address: sanyog.shitole@ucsf.edu.
Mark H KuniholmUniversity at Albany, 1 University Place, Rensselaer, NY, 12144, USA.
David B HannaAlbert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA.
Thomas BoucherAlbert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA.
Angel Y PengMontefiore Health System, 3311 Bainbridge Avenue, Bronx, NY, 10467, USA.
Cecilia BerardiYale-New Haven Hospital, 20 York Street, New Haven, CT, 06510, USA.
Tina ShahMontefiore Health System, 3311 Bainbridge Avenue, Bronx, NY, 10467, USA.
Anna E BortnickAlbert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA; Montefiore Health System, 3311 Bainbridge Avenue, Bronx, NY, 10467, USA.
Panagiota ChristiaMount Sinai Heart-Mount Sinai Medical Center, 1468 Madison Avenue, New York, NY, 10029, USA.
James ScheuerAlbert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA; Montefiore Health System, 3311 Bainbridge Avenue, Bronx, NY, 10467, USA.
Jorge R KizerUniversity of California San Francisco and San Francisco Veterans Affairs Health Care System, 4150 Clement Street, San Francisco, CA, 94121, USA.
Albert Einstein College of Medicine · USMontefiore Health System · USUniversity of California, San Francisco · USMount Sinai Medical Center · USUniversity at Albany, State University of New York · USYale New Haven Hospital · US

Funding

Patient and Population Health Outcomes Research SWGP30AI124414 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Vilma Gabbay · 2017 to 2026
$28.3M
MWCCS: Brooklyn Clinical Research SiteU01HL146202 · NHLBI · SUNY DOWNSTATE MEDICAL CENTER · PI TRACEY ELIZABETH WILSON, Jessica Eve Yager · 2019 to 2026
$23.6M
Prediction of heart failure in HIV-infected individualsK01HL137557 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI HANNA, DAVID B. · 2017 to 2020
$711k
Advanced Glycation Endproducts and Cardio-Renal DiseaseK24HL135413 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KIZER, JORGE R · 2017 to 2021
$606k
NHLBI NIH HHS K01 HL137557NHLBI NIH HHS K24 HL135413NHLBI NIH HHS U01 HL146202NIAID NIH HHS P30 AI124414
6 · The paper itself

Abstract

backgroundHIV and HCV have been linked to an increased risk of cardiovascular disease (CVD). Their impact on long-term outcomes following ST-segment myocardial infarction (STEMI) has not been previously studied.

methodsWe leveraged data from a STEMI registry (n = 1208) at an inner-city health system to assess the influence of HIV and HCV on post-STEMI outcomes. Cox regression was used to compare HIV-monoinfected (n = 22), HCV-monoinfected (n = 26) and HIV-HCV-coinfected patients (n = 8) with the neither-infected group (n = 1152) with regard to death, death or any readmission, and death or CVD readmission.

resultsThe cohort was majority black or Hispanic. Median follow-up was 4.3 years. Compared to the neither-infected group, the HIV-monoinfected group showed near-significantly higher risks of death or any readmission (HR = 1.62, 95% CI = 0.96, 2.74) and death or CVD readmission (HR = 1.82, 95% CI = 0.98, 3.39) after full adjustment. On similar comparison, the HCV-monoinfected group exhibited significantly higher risks of death (HR = 2.09, 95% CI = 1.05, 4.15) and death or any readmission (HR = 1.68, 95% CI = 1.07, 2.65), whereas the HIV-HCV-coinfected group showed higher risk of death (HR = 6.51, 95% CI = 2.28, 18.61).

conclusionsIn this cohort composed mostly of race-ethnic minorities, HIV monoinfection tended to be associated with 1.6-to-1.8-fold higher risk of death or readmission for any cause or CVD over long-term follow-up compared to neither infection, whereas HCV monoinfection was associated with 1.7-to-2.1-fold higher risk of death and death or any readmission, and HIV-HCV coinfection with 6.5-fold higher risk of death. These associations require further study in larger populations, but highlight the importance of identifying and treating HIV and HCV in patients presenting with STEMI.

Indexed as

CoinfectionHepatitis CHepatitis C, ChronicHIV InfectionsST Elevation Myocardial InfarctionHepacivirusHIVHumansVulnerable PopulationsHCVHIVOutcomesSTEMI

Identifiers

PMID32947199
PMCPMC7572633
OpenAlexW3082725036

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.