ArticleNeuroImage2021
Robustness of connectome harmonics to local gray matter and long-range white matter connectivity changes.
Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Functional harmonics reveal multi-dimensional basis functions underlying cortical organization.Cell reports · 2021Trial
- Spectral organization of individualized connectome harmonics across brain structure, function and cognition.bioRxiv : the preprint server for biology · 2026Article
- Shannon Entropy of Gray Matter Eigenmodes: A Novel Biomarker for Alzheimer's Disease and Heterogeneous MCI Trajectories.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- From Electron Imbalance to Network Collapse: Decoding the Redox Code of Ischemic Stroke for Biomarker-Guided Precision Neuroprotection.International journal of molecular sciences · 2025Review
- N,N-dimethyltryptamine effects on connectome harmonics, subjective experience and comparative psychedelic experiences.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- The neuroreceptors and transporters underlying spontaneous brain activity.Communications biology · 2025Article
- Neural dynamics of semantic control underlying generative storytelling.Communications biology · 2025Article
- Time-resolved coupling between connectome harmonics and subjective experience under the psychedelic DMT.bioRxiv : the preprint server for biology · 2024Article
- Connectome spectrum electromagnetic tomography: A method to reconstruct electrical brain source networks at high-spatial resolution.Human brain mapping · 2024Article
- Decomposing cortical activity through neuronal tracing connectome-eigenmodes in marmosets.Nature communications · 2024Article
- Mode-based morphometry: A multiscale approach to mapping human neuroanatomy.Human brain mapping · 2024Article
- Geometric constraints on human brain function.Nature · 2023Article
- Estimating Outlier-Immunized Common Harmonic Waves for Brain Network Analyses on the Stiefel Manifold.IEEE journal of biomedical and health informatics · 2023Article
- Mode-based morphometry: A multiscale approach to mapping human neuroanatomy.bioRxiv : the preprint server for biology · 2023Article
- Distributed harmonic patterns of structure-function dependence orchestrate human consciousness.Communications biology · 2023Article
- Article
- Edges in brain networks: Contributions to models of structure and function.Network neuroscience (Cambridge, Mass.) · 2022Review
- Predicting Functional Connectivity From Observed and Latent Structural ConnectivityFrontiers in neuroscience · 2022Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recently, it has been proposed that the harmonic patterns emerging from the brain's structural connectivity underlie the resting state networks of the human brain. These harmonic patterns, termed connectome harmonics, are estimated as the Laplace eigenfunctions of the combined gray and white matters connectivity matrices and yield a connectome-specific extension of the well-known Fourier basis. However, it remains unclear how topological properties of the combined connectomes constrain the precise shape of the connectome harmonics and their relationships to the resting state networks. Here, we systematically study how alterations of the local and long-range connectivity matrices affect the spatial patterns of connectome harmonics. Specifically, the proportion of local gray matter homogeneous connectivity versus long-range white-matter heterogeneous connectivity is varied by means of weight-based matrix thresholding, distance-based matrix trimming, and several types of matrix randomizations. We demonstrate that the proportion of local gray matter connections plays a crucial role for the emergence of wide-spread, functionally meaningful, and originally published connectome harmonic patterns. This finding is robust for several different cortical surface templates, mesh resolutions, or widths of the local diffusion kernel. Finally, using the connectome harmonic framework, we also provide a proof-of-concept for how targeted structural changes such as the atrophy of inter-hemispheric callosal fibers and gray matter alterations may predict functional deficits associated with neurodegenerative conditions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.