Evidence map›Paper›PMID 32946981›Full record

ArticleExperimental hematology2020

Human pediatric B-cell acute lymphoblastic leukemias can be classified as B-1 or B-2-like based on a minimal transcriptional signature.

Briana Fitch, Ritu Roy, Huimin Geng, Encarnacion Montecino-Rodriguez, Henrik Bengtsson, Coline Gaillard, Kamir Hiam, David Casero, Adam B Olshen, Kenneth Dorshkind and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental hematology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Briana FitchDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA.
Ritu RoyHelen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA; Computational Biology and Informatics, University of California, San Francisco, San Francisco, CA.
Huimin GengDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA.
Encarnacion Montecino-RodriguezDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA.
Henrik BengtssonHelen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA.
Coline GaillardDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA.
Kamir HiamHelen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA.
David CaseroDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA.
Adam B OlshenHelen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA; Computational Biology and Informatics, University of California, San Francisco, San Francisco, CA; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA.
Kenneth DorshkindDepartment of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA.
Scott C KoganDepartment of Laboratory Medicine, University of California, San Francisco, San Francisco, CA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA. Electronic address: Scott.Kogan@ucsf.edu.
University of California, San Francisco · USUniversity of California, Los Angeles · US

Funding

Translational InformaticsP30CA082103 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kate Taylor Shumate · 1999 to 2026
$209.7M
Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
Impact of B-Cell Lineage on Progression of B-Acute Lymphoblastic LeukemiaR21CA173028 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DORSHKIND, KENNETH ALLAN, KOGAN, SCOTT C. · 2013 to 2014
$380k
Mechanism of IL-10 protective effect in development of childhood B cell acute lymphoblastic leukemiaF31CA221157 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FITCH, BRIANA · 2017 to 2019
$104k
NCI NIH HHS F31 CA221157NCI NIH HHS P30 CA016042NCI NIH HHS P30 CA082103NCI NIH HHS R21 CA173028
6 · The paper itself

Abstract

The finding that transformed mouse B-1 and B-2 progenitors give rise to B-cell acute lymphoblastic leukemias (B-ALLs) with varied aggressiveness suggests that B-cell lineage might also be a factor in the initiation and progression of pediatric B-ALLs in humans. If this is the case, we hypothesized that human pediatric B-ALLs would share gene expression patterns with mouse B-1 or B-2 progenitors. We tested this premise by deriving a distinct 30-gene B-1 and B-2 progenitor signature that was applied to a microarray data set of human pediatric ALLs. Cluster analysis revealed that CRLF2, E2A-PBX1, ERG, and ETV6-RUNX1 leukemias were B-1-like, whereas BCR-ABL1, hyperdiploid, and MLL leukemias were B-2-like. Examination of the 30-gene signature in two independent data sets of pediatric ALLs supported this result. Our data suggest that common genetic subtypes of human ALL have their origin in the B-1 or B-2 lineage.

Indexed as

Gene Expression ProfilingGene Expression Regulation, LeukemicNeoplasm ProteinsPrecursor T-Cell Lymphoblastic Leukemia-LymphomaTranscriptomeAnimalsChildHumansMiceNeoplasm Proteins

Identifiers

PMID32946981
PMCPMC7606616
OpenAlexW3085648431

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.