Trial reportDiabetes research and clinical practice2020
The associations between fasting plasma glucose levels and mortality of COVID-19 in patients without diabetes.
Trial report in Diabetes research and clinical practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Identification of Parameters Representative of Immune Dysfunction in Patients with Severe and Fatal COVID-19 Infection: a Systematic Review and Meta-analysis.Clinical reviews in allergy & immunology · 2023Pooled it
- Prospective multicentre study of upper respiratory mucosal transcriptomics reveals two major endotypes of critically ill COVID-19 patients.Communications medicine · 2026Article
- Correlation between the neutrophil-to-lymphocyte ratio and the 90-day all-cause mortality in patients with acute respiratory failure: a retrospective analysis based on the MIMIC-IV Database.BMC cardiovascular disorders · 2025Article
- Identification of key gene expression associated with quality of life after recovery from COVID-19.Medical & biological engineering & computing · 2024Article
- Night eating in timing, frequency, and food quality and risks of all-cause, cancer, and diabetes mortality: findings from national health and nutrition examination survey.Nutrition & diabetes · 2024Article
- Exploring the Potential Association between COVID-19 and Thyroid Cancer: A Mendelian Randomization Study.ACS omega · 2023Article
- Predictive markers related to local and systemic inflammation in severe COVID-19-associated ARDS: a prospective single-center analysis.BMC infectious diseases · 2023Article
- CXCL8, CCL2, and CMV Seropositivity as New Prognostic Factors for a Severe COVID-19 Course.International journal of molecular sciences · 2022Article
- J-shaped associations and joint effects of fasting glucose with inflammation and cytokines on COVID-19 mortality.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022Article
- Heterogeneity and Risk of Bias in Studies Examining Risk Factors for Severe Illness and Death in COVID-19: A Systematic Review and Meta-Analysis.Pathogens (Basel, Switzerland) · 2022Review
- Newly Diagnosed Diabetes Mellitus During COVID-19: The New Pandemic - A Literature Review.Current tropical medicine reports · 2022Review
- Diabetes, Metformin and the Clinical Course of Covid-19: Outcomes, Mechanisms and Suggestions on the Therapeutic Use of Metformin.Frontiers in pharmacology · 2022Review
- Development and Validation of a Nomogram for Predicting the Risk of Coronavirus-Associated Acute Respiratory Distress Syndrome: A Retrospective Cohort Study.Infection and drug resistance · 2022Article
- The Role of Diabetes and Hyperglycemia on COVID-19 Infection Course-A Narrative Review.Frontiers in clinical diabetes and healthcare · 2022Review
- Is There a Link between COVID-19 Infection, Periodontal Disease and Acute Myocardial Infarction?Life (Basel, Switzerland) · 2021Review
- The prognostic role of hyperglycemia and glucose variability in covid-related acute respiratory distress Syndrome.Diabetes research and clinical practice · 2021Article
- Diabetes, obesity, metabolism, and SARS-CoV-2 infection: the end of the beginning.Cell metabolism · 2021Review
- A narrative review on characterization of acute respiratory distress syndrome in COVID-19-infected lungs using artificial intelligence.Computers in biology and medicine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsCoronavirus disease 2019 (COVID-19) which is a novel pneumonia can rapidly progress to acute respiratory distress syndrome, septic shock, and multiple organ dysfunction syndrome. It has appeared in 196 countries around the world. We aimed to clarify the associations between fasting plasma glucose levels and mortality of COVID-19 in patients without diabetes.
methodsWe performed a retrospective, single-center study of 151 patients without diabetes in Tongji Hospital from January 1, 2020 to February 28, 2020. Past medical histories, clinical features and laboratory parameters were collected in these patients.
resultsCompared with survivors, non-survivors were more likely to have underlying medical conditions including hypertension and chronic pulmonary diseases. Non-survivors had higher C-reactive protein (CRP), procalcitonin (PCT), interleukin (IL)-2R, IL-6, IL-8 and, tumor necrosis factor-α (TNF-α) levels, while lower lymphocyte counts as compared with those of survivors (all P<0.05). Besides, patients with higher fasting plasma glucose (FPG) had higher IL-6, IL-8, CRP levels and mortality; while lower lymphocyte counts. After adjusting for age and gender, each tertile increment of FPG levels conferred 3.54-fold higher risks of death (odds ratio, 3.54; 95% confidential interval, 1.25-10.06, P=0.018).
conclusionsNon-survivors combined with more comorbidities, more severe infection, and worse liver, kidney and cardiac function in patients without diabetes. Additionally, fasting plasma glucose levels were significantly associated with the risk of death in patients even with normal FPG and HbA1c levels.
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