Evidence map›Paper›PMID 32946822›Full record

ReviewThe lancet. Diabetes & endocrinology2020

Diabetes in ageing: pathways for developing the evidence base for clinical guidance.

Medha N Munshi, Graydon S Meneilly, Leocadio Rodríguez-Mañas, Kelly L Close, Paul R Conlin, Tali Cukierman-Yaffe, Angus Forbes, Om P Ganda, C Ronald Kahn, Elbert Huang and 8 more

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The lancet. Diabetes & endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07591415 (Validation of an App in the Elderly Population With Diabetes Mellitus.), which is not on this map. Cited by 48 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 2 pooled it
6.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07591415 nacompletednot on this mapstarted 2025, after this paper: background citation

Validation of an App in the Elderly Population With Diabetes Mellitus.

TypeinterventionalSponsorLeocadio Rodriguez MañasRan2025 to 2025Enrolled60ConditionsDiabetes, Diabetes Mellitus, Elderly, ELDERLY PEOPLEArmsSmartdiabetes
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 100 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Developing an Intervention for Safe Hospital Insulin Use for Older Adults With Diabetes Undergoing Surgical Admission (SHINE Study): A Co-Design Study.Health expectations : an international journal of public participation in health care and health policy · 2026
    Article
  8. Article
  9. Review
  10. Article
  11. Observational
  12. Article
  13. 'Why, Can I Not Have Control of My Own Insulin?': Qualitative Exploration Amongst Older Adults With Diabetes With Lived Experience of Surgical Hospital Admission.Health expectations : an international journal of public participation in health care and health policy · 2025
    Article
  14. Bioactives in Food-As-Medicine for Special Medical Purposes.Advances in nutrition (Bethesda, Md.) · 2025
    Review
  15. Review
  16. Article
  17. Clin-STAR Corner: Practice Changing Advances in Diabetes Care.Journal of the American Geriatrics Society · 2025
    Review
  18. Observational
  19. Review
  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 14 institutions in 5 countries.

Medha N MunshiHarvard Medical School, Boston, MA, USA; Joslin Diabetes Center, Boston, MA, USA; Beth Israel Deaconess Medical Center, Boston, MA, USA. Electronic address: mmunshi@bidmc.harvard.edu.
Graydon S MeneillyUniversity of British Columbia, Vancouver, BC, Canada.
Leocadio Rodríguez-MañasServicio de Geriatria, Hospital Universitario de Getafe, Getafe, Spain.
Kelly L CloseThe diaTribe Foundation San Francisco, CA, USA; Close Concerns, San Francisco, CA, USA.
Paul R ConlinHarvard Medical School, Boston, MA, USA; Veteran Affairs Boston Healthcare System, Boston, MA, USA.
Tali Cukierman-YaffeDivision of Endocrinology, Diabetes and Metabolism, Gertner Institute, Ramat Gan, Israel; Sheba Medical Centre, Ramat Gan, Israel; Epidemiology Department, Sackler School of Medicine, Herczeg Institute on Aging, Tel Aviv University, Tel Aviv, Israel.
Angus ForbesKing's College London, London, UK.
Om P GandaHarvard Medical School, Boston, MA, USA; Joslin Diabetes Center, Boston, MA, USA.
C Ronald KahnHarvard Medical School, Boston, MA, USA; Joslin Diabetes Center, Boston, MA, USA.
Elbert HuangCenter for Chronic Disease Research and Policy, Section of General Internal Medicine, University of Chicago, Chicago, IL, USA.
Lori M LaffelHarvard Medical School, Boston, MA, USA; Joslin Diabetes Center, Boston, MA, USA.
Christine G LeeDivision of Diabetes, Endocrinology and Metabolic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Sei LeeUniversity of California San Francisco, San Francisco, CA, USA; Geriatrics and Extended Care, San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA.
David M NathanHarvard Medical School, Boston, MA, USA; Diabetes Research Center and Clinical Research Center, Massachusetts General Hospital, Boston, MA, USA.
Naushira PandyaDepartment of Geriatrics, Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Aventura Hospital, Aventura, FL, USA.
Richard PratleyAdventHealth, AdventHealth Diabetes Institute, AdventHealth Translational Research Institute, Orlando, FL, USA.
Robert GabbayHarvard Medical School, Boston, MA, USA; Joslin Diabetes Center, Boston, MA, USA.
Alan J SinclairKing's College London, London, UK; Diabetes Frail, London, UK.
Harvard University · USJoslin Diabetes Center · USAventura Hospital and Medical Center · USClose Concerns (United States) · USDiabetes UK · GBHospital Universitario de Getafe · ESKing's College London · GBMassachusetts General Hospital · USNational Institute of Diabetes and Digestive and Kidney Diseases · USSheba Medical Center · ILTranslational Research Institute for Metabolism and Diabetes · USUniversity of British Columbia · CAUniversity of California, San Francisco · USUniversity of Chicago · US

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 1986 to 2026
$50.5M
Research Design, Data, and Analytics CoreP30DK092949 · NIDDK · UNIVERSITY OF CHICAGO · PI MILDA Renne SAUNDERS · 2011 to 2026
$10.0M
The Insulin Receptor and Its Signaling MechanismsR01DK031036 · NIDDK · JOSLIN DIABETES CENTER · PI C RONALD KAHN · 1986 to 2026
$4.2M
Optimizing Medical Decision Making for Older Patients with Type 2 DiabetesR01AG063391 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI HUANG, ELBERT S., KARTER, ANDREW JOHN · 2019 to 2023
$3.2M
Hemoglobin A1C Variability as a Risk Factor for Diabetes ComplicationsR01DK114098 · NIDDK · HARVARD MEDICAL SCHOOL · PI CONLIN, PAUL R · 2019 to 2022
$2.3M
Research and Mentorship in Medical Decision Making in DiabetesK24DK105340 · NIDDK · UNIVERSITY OF CHICAGO · PI HUANG, ELBERT S. · 2015 to 2019
$884k
Research and Mentorship in Medical Decision Making for Chronic Diseases of Older AdultsK24AG069080 · NIA · UNIVERSITY OF CHICAGO · PI HUANG, ELBERT S. · 2020 to 2024
$583k
NIA NIH HHS K24 AG069080NIA NIH HHS R01 AG063391NIDDK NIH HHS K24 DK105340NIDDK NIH HHS P30 DK036836NIDDK NIH HHS P30 DK092949NIDDK NIH HHS R01 DK031036NIDDK NIH HHS R01 DK114098
6 · The paper itself

Abstract

Older adults with diabetes are heterogeneous in their medical, functional, and cognitive status, and require careful individualisation of their treatment regimens. However, in the absence of detailed information from clinical trials involving older people with varying characteristics, there is little evidence-based guidance, which is a notable limitation of current approaches to care. It is important to recognise that older people with diabetes might vary in their profiles according to age category, functional health, presence of frailty, and comorbidity profiles. In addition, all older adults with diabetes require an individualised approach to care, ranging from robust individuals to those residing in care homes with a short life expectancy, those requiring palliative care, or those requiring end-of-life management. In this Review, our multidisciplinary team of experts describes the current evidence in several important areas in geriatric diabetes, and outlines key research gaps and research questions in each of these areas with the aim to develop evidence-based recommendations to improve the outcomes of interest in older adults.

Indexed as

AgingAgedAged, 80 and overDiabetes MellitusHumansPatient-Centered CarePractice Guidelines as Topic

Identifiers

PMID32946822
PMCPMC8223534
OpenAlexW3085703194

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.