Evidence map›Paper›PMID 32946810›Full record

ArticleCell2020

Neuronal Computation Underlying Inferential Reasoning in Humans and Mice.

Helen C Barron, Hayley M Reeve, Renée S Koolschijn, Pavel V Perestenko, Anna Shpektor, Hamed Nili, Roman Rothaermel, Natalia Campo-Urriza, Jill X O'Reilly, David M Bannerman and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 185 citations in OpenAlex.

  1. Article
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  4. The hippocampus as a generative model.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026
    Review
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  17. Prediction error and memory updating: Challenges ahead.Neuroscience and biobehavioral reviews · 2025
    Article
  18. Article
  19. Article
  20. Article

30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Helen C BarronMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK; Wellcome Centre for Integrative Neuroimaging, University of Oxford, FMRIB, John Radcliffe Hospital, Oxford OX3 9DU, UK. Electronic address: helen.barron@merton.ox.ac.uk.
Hayley M ReeveMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK.
Renée S KoolschijnWellcome Centre for Integrative Neuroimaging, University of Oxford, FMRIB, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Pavel V PerestenkoMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK.
Anna ShpektorWellcome Centre for Integrative Neuroimaging, University of Oxford, FMRIB, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Hamed NiliWellcome Centre for Integrative Neuroimaging, University of Oxford, FMRIB, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Roman RothaermelMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK.
Natalia Campo-UrrizaMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK.
Jill X O'ReillyWellcome Centre for Integrative Neuroimaging, University of Oxford, FMRIB, John Radcliffe Hospital, Oxford OX3 9DU, UK; Department of Experimental Psychology, University of Oxford, 15 Parks Road, Oxford OX1 3AQ, UK.
David M BannermanDepartment of Experimental Psychology, University of Oxford, 15 Parks Road, Oxford OX1 3AQ, UK.
Timothy E J BehrensWellcome Centre for Integrative Neuroimaging, University of Oxford, FMRIB, John Radcliffe Hospital, Oxford OX3 9DU, UK; The Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, UK.
David DupretMedical Research Council Brain Network Dynamics Unit, Nuffield Department of Clinical Neurosciences, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK. Electronic address: david.dupret@bndu.ox.ac.uk.
University of Oxford · GBJohn Radcliffe Hospital · GBWellcome Centre for Human Neuroimaging · GB

Funding

Biotechnology and Biological Sciences Research Council BB/N0059TX/1Medical Research Council MC_UU_00003/4Medical Research Council MC_UU_12024/3Medical Research Council MR/T031344/1Wellcome Trust 104765Wellcome Trust 203139Wellcome Trust 203836Wellcome Trust 203964
6 · The paper itself

Abstract

Every day we make decisions critical for adaptation and survival. We repeat actions with known consequences. But we also draw on loosely related events to infer and imagine the outcome of entirely novel choices. These inferential decisions are thought to engage a number of brain regions; however, the underlying neuronal computation remains unknown. Here, we use a multi-day cross-species approach in humans and mice to report the functional anatomy and neuronal computation underlying inferential decisions. We show that during successful inference, the mammalian brain uses a hippocampal prospective code to forecast temporally structured learned associations. Moreover, during resting behavior, coactivation of hippocampal cells in sharp-wave/ripples represent inferred relationships that include reward, thereby "joining-the-dots" between events that have not been observed together but lead to profitable outcomes. Computing mnemonic links in this manner may provide an important mechanism to build a cognitive map that stretches beyond direct experience, thus supporting flexible behavior.

Indexed as

AnimalsBrainDecision MakingFemaleHippocampusHumansMaleMemoryMiceMice, Inbred C57BLModels, NeurologicalNerve NetNeuronsProspective StudiesThinkingYoung Adultcognitive mapcognitive short-cuthippocampushumansinferencememorymiceprospective codesharp-wave ripple

Identifiers

PMID32946810
PMCPMC7116148
OpenAlexW3070427138

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.