Evidence map›Paper›PMID 32946770›Full record

ArticleBiophysical journal2020

Dimerization of SERCA2a Enhances Transport Rate and Improves Energetic Efficiency in Living Cells.

Elisa Bovo, Roman Nikolaienko, Sean R Cleary, Jaroslava Seflova, Daniel Kahn, Seth L Robia, Aleksey V Zima

Open access · bronzeAbstract read
In one paragraph

Article in Biophysical journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. P-type ATPase magnesium transporter MgtA acts as a dimer.Nature structural & molecular biology · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Regulation of cardiac calcium signaling by newly identified calcium pump modulators.Biochemical and biophysical research communications · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Elisa BovoDepartment of Cell and Molecular Physiology, Loyola University Chicago, Chicago, Illinois.
Roman NikolaienkoDepartment of Cell and Molecular Physiology, Loyola University Chicago, Chicago, Illinois.
Sean R ClearyDepartment of Cell and Molecular Physiology, Loyola University Chicago, Chicago, Illinois.
Jaroslava SeflovaDepartment of Cell and Molecular Physiology, Loyola University Chicago, Chicago, Illinois.
Daniel KahnDepartment of Cell and Molecular Physiology, Loyola University Chicago, Chicago, Illinois.
Seth L RobiaDepartment of Cell and Molecular Physiology, Loyola University Chicago, Chicago, Illinois.
Aleksey V ZimaDepartment of Cell and Molecular Physiology, Loyola University Chicago, Chicago, Illinois. Electronic address: azima@luc.edu.
Loyola University Chicago · US

Funding

Structural Determinants of Calcium Pump RegulationR01HL092321 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI Seth L Robia · 2008 to 2026
$8.9M
Structural Dynamics of Cardiac Muscle Calcium ATPase RegulationR01HL139065 · NHLBI · UNIVERSITY OF MINNESOTA · PI Robyn T Rebbeck, David D Thomas · 2020 to 2026
$5.2M
New mechanisms of SERCA regulation: Dimerization and MicropeptidesR01HL143816 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI Seth L Robia, Gianluigi Veglia · 2019 to 2026
$3.6M
Calcium release channel dysfunction: molecular mechanismsR01HL130231 · NHLBI · LOYOLA UNIVERSITY CHICAGO · PI ZIMA, ALEKSEY V · 2016 to 2019
$1.5M
NHLBI NIH HHS R01 HL092321NHLBI NIH HHS R01 HL130231NHLBI NIH HHS R01 HL139065NHLBI NIH HHS R01 HL143816
6 · The paper itself

Abstract

The type 2a sarco/endoplasmic reticulum (ER) Ca

Indexed as

CalciumSarcoplasmic Reticulum Calcium-Transporting ATPasesDimerizationHEK293 CellsHumansRyanodine Receptor Calcium Release ChannelSarcoplasmic ReticulumCalciumRyanodine Receptor Calcium Release ChannelSarcoplasmic Reticulum Calcium-Transporting ATPases

Identifiers

PMID32946770
PMCPMC7567987
OpenAlexW3082845833

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.