Evidence map›Paper›PMID 32946767›Full record

ArticleBiophysical journal2020

Native Cell Environment Constrains Loop Structure in the Escherichia coli Cobalamin Transporter BtuB.

David A Nyenhuis, Thushani D Nilaweera, David S Cafiso

Open access · bronzeAbstract read
In one paragraph

Article in Biophysical journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. HDX-MS performed on BtuB inProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

David A NyenhuisDepartment of Chemistry and Center for Membrane Biology, University of Virginia, Charlottesville, Virginia.
Thushani D NilaweeraDepartment of Chemistry and Center for Membrane Biology, University of Virginia, Charlottesville, Virginia.
David S CafisoDepartment of Chemistry and Center for Membrane Biology, University of Virginia, Charlottesville, Virginia. Electronic address: cafiso@virginia.edu.
University of Virginia · US

Funding

MOLECULAR MECHANISMS OF MEMBRANE TRANSPORTR01GM035215 · NIGMS · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI DAVID S CAFISO · 1985 to 2026
$7.3M
Training in Molecular BiophysicsT32GM080186 · NIGMS · UNIVERSITY OF VIRGINIA · PI NAKAMOTO, ROBERT K. · 2008 to 2019
$1.5M
Upgrade of Bruker EPR SpectrometerS10OD025149 · OD · UNIVERSITY OF VIRGINIA · PI CAFISO, DAVID S · 2018 to 2018
$396k
NIGMS NIH HHS R01 GM035215NIGMS NIH HHS T32 GM080186NIH HHS S10 OD025149
6 · The paper itself

Abstract

The extracellular loops of bacterial outer membrane (OM) transporters are thought to sample a range of conformations in the apo state but to undergo a gating motion and assume a more defined conformation upon the binding of substrate. Here, we use pulse electron paramagnetic resonance to examine the conformations of the extracellular loops of BtuB, the Escherichia coli TonB-dependent vitamin B

Indexed as

Escherichia coliEscherichia coli ProteinsBacterial Outer Membrane ProteinsMembrane Transport ProteinsVitamin B 12Bacterial Outer Membrane ProteinsEscherichia coli ProteinsMembrane Transport ProteinsVitamin B 12

Identifiers

PMID32946767
PMCPMC7642247
OpenAlexW3083474611

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.