Evidence map›Paper›PMID 32946744›Full record

ArticleNeuron2020

Wireless Programmable Recording and Stimulation of Deep Brain Activity in Freely Moving Humans.

Uros Topalovic, Zahra M Aghajan, Diane Villaroman, Sonja Hiller, Leonardo Christov-Moore, Tyler J Wishard, Matthias Stangl, Nicholas R Hasulak, Cory S Inman, Tony A Fields and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 87 citations in OpenAlex.

  1. A guide to neuromodulation in drug-resistant epilepsy.Epileptic disorders : international epilepsy journal with videotape · 2026
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  10. Revisiting the role of computational neuroimaging in the era of integrative neuroscience.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Uros TopalovicDepartment of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90024, USA.
Zahra M AghajanDepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90024, USA.
Diane VillaromanDepartment of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Sonja HillerDepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90024, USA.
Leonardo Christov-MooreDepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90024, USA.
Tyler J WishardDepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90024, USA.
Matthias StanglDepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90024, USA.
Nicholas R HasulakNeuroPace, Mountain View, CA 94043, USA.
Cory S InmanDepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90024, USA.
Tony A FieldsDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Vikram R RaoDepartment of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94143, USA.
Dawn EliashivDepartment of Neurology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Itzhak FriedDepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90024, USA; Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Tel Aviv Sourasky Medical Center and Sackler Faculty School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.
Nanthia SuthanaDepartment of Psychiatry and Biobehavioral Sciences, Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA 90024, USA; Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: nsuthana@mednet.ucla.edu.
University of California, Los Angeles · USNeuroPace (United States) · USUniversity of California, San Francisco · US

Funding

Neurostimulation and Recording of Real World Spatial Navigation in HumansU01NS117838 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUTHANA, NANTHIA A · 2020 to 2024
$5.3M
Neurostimulation and Recording of Real World Spatial Navigation in HumansU01NS103802 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUTHANA, NANTHIA A · 2017 to 2019
$3.4M
Training Program in Neural MicrocircuitsT32NS058280 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FELDMAN, JACK L · 2007 to 2017
$2.4M
NINDS NIH HHS T32 NS058280NINDS NIH HHS U01 NS103802NINDS NIH HHS U01 NS117838
6 · The paper itself

Abstract

Uncovering the neural mechanisms underlying human natural ambulatory behavior is a major challenge for neuroscience. Current commercially available implantable devices that allow for recording and stimulation of deep brain activity in humans can provide invaluable intrinsic brain signals but are not inherently designed for research and thus lack flexible control and integration with wearable sensors. We developed a mobile deep brain recording and stimulation (Mo-DBRS) platform that enables wireless and programmable intracranial electroencephalographic recording and electrical stimulation integrated and synchronized with virtual reality/augmented reality (VR/AR) and wearables capable of external measurements (e.g., motion capture, heart rate, skin conductance, respiration, eye tracking, and scalp EEG). When used in freely moving humans with implanted neural devices, this platform is adaptable to ecologically valid environments conducive to elucidating the neural mechanisms underlying naturalistic behaviors and to the development of viable therapies for neurologic and psychiatric disorders.

Indexed as

Psychomotor PerformanceWearable Electronic DevicesAugmented RealityBrainDeep Brain StimulationElectroencephalographyHumansSignal Processing, Computer-AssistedSoftwareTelemetryVirtual Realityaugmented realityeye trackinghumanintracranial EEGintracranial electrical stimulationmobile EEGneuroimaging methodsvirtual realitywearables

Identifiers

PMID32946744
PMCPMC7785319
OpenAlexW3086805565

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.