ArticleEmerging infectious diseases2020
Association between Shiga Toxin-Producing Escherichia coli O157:H7 stx Gene Subtype and Disease Severity, England, 2009-2019.
Article in Emerging infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 50 citations in OpenAlex.
- Health effects of street vended fresh cut fruits: A randomized controlled trial in Bangladesh.PloS one · 2025Trial
- Surveillance of enteropathogenicJournal of medical microbiology · 2026Article
- Shiga toxin increases intestinal transit to displace resident microbes and facilitate pathogen colonization.PLoS pathogens · 2026Article
- First Reported Outbreak of Persistent Shiga Toxin-producingOpen forum infectious diseases · 2026Article
- Mind the gap! TypingMicrobial genomics · 2026Article
- An outbreak of Shiga toxin-producingEpidemiology and infection · 2026Article
- Shiga toxin-producing Escherichia coli plasmid diversity reveals virulence potential and control opportunities in animal hosts.Scientific reports · 2025Article
- Genomic Characterization of Escherichia coli O157:H7 Associated with Multiple Sources, United States.Emerging infectious diseases · 2025Article
- Comparative genomics of Shiga toxin-producingFrontiers in veterinary science · 2025Article
- Epidemiology of Shiga toxin-producingJournal of medical microbiology · 2025Article
- Genotypic analysis of Shiga toxin-producingJournal of medical microbiology · 2024Article
- Clinical Outcomes and Virulence Factors of Shiga Toxin-ProducingPathogens (Basel, Switzerland) · 2024Article
- An outbreak of Shiga toxin-producingEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2024Article
- A Health Threat from Farm to Fork: Shiga Toxin-ProducingPathogens (Basel, Switzerland) · 2024Article
- Farm animal exposure setting impacts hemolytic uremic syndrome risk among Shiga toxin-producingEpidemiology and infection · 2024Article
- Re-analysis of an outbreak of Shiga toxin-producing Escherichia coli O157:H7 associated with raw drinking milk using Nanopore sequencing.Scientific reports · 2024Article
- Combined usage of serodiagnosis and O antigen typing to isolate Shiga toxin-producingMicrobiology spectrum · 2024Article
- The diverse landscape of AB5-type toxins.Engineering microbiology · 2023Review
- Genetic Characterization of Intimin Gene (Toxins · 2023Article
- Animal and environmental risk factors for sporadic Shiga toxin-producing Escherichia coli (STEC) infection in England: a case control study for O157, O26 and other STEC serotypes.Pathogens and global health · 2023Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Signs and symptoms of Shiga toxin-producing Escherichia coli (STEC) serogroup O157:H7 infection range from mild gastrointestinal to bloody diarrhea and hemolytic uremic syndrome (HUS). We assessed the association between Shiga toxin gene (stx) subtype and disease severity for »3,000 patients with STEC O157:H7 in England during 2009-2019. Odds of bloody diarrhea, HUS, or both, were significantly higher for patients infected with STEC O157:H7 possessing stx2a only or stx2a combined with other stx subtypes. Odds of severe signs/symptoms were significantly higher for isolates encoding stx2a only and belonging to sublineage Ic and lineage I/II than for those encoding stx2a only and belonging to sublineage IIb, indicating that stx2a is not the only driver causing HUS. Strains of STEC O157:H7 that had stx1a were also significantly more associated with severe disease than strains with stx2c only. This finding confounds public health risk assessment algorithms based on detection of stx2 as a predictor of severe disease.
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