ArticlePLoS neglected tropical diseases2020
Impact of a 3-year mass drug administration pilot project for taeniasis control in Madagascar.
Article in PLoS neglected tropical diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Neurocysticercosis control for primary epilepsy prevention: a systematic review.Pathogens and global health · 2022Pooled it
- Epidemiology of Porcine Cysticercosis in Eastern and Southern Africa: Systematic Review and Meta-Analysis.Frontiers in public health · 2022Pooled it
- Pooled it
- Taenia solium neurocysticercosis: Its current epidemiological, diagnostic, therapeutic, and control landscapes.PLoS neglected tropical diseases · 2026Review
- Evaluation of a One Health public health program based on minimum inputs to control Taenia solium in Madagascar.PLoS neglected tropical diseases · 2025Article
- Repurposing statins for the treatment of larval cestodiases:Parasitology · 2025Article
- Prevention and improved management of serious neurological adverse events during praziquantel-based mass drug administration in a Taenia solium endemic area: Experiences from Madagascar.PLoS neglected tropical diseases · 2025Article
- Schistosomiasis and Intestinal Helminthiases in a Remote Area of Central Madagascar.Journal of tropical medicine · 2025Article
- Effect of Community Health Education Intervention on Prevalence and Pig Farmers' Knowledge, Attitudes, and Practices Related to Porcine Cysticercosis in Selected Areas of Tanzania.Veterinary medicine international · 2025Article
- Spatial transferability of an agent-based model to simulate Taenia solium control interventions.Parasites & vectors · 2023Article
- Comparison of Kato-Katz, PCR and coproantigen for the diagnosis ofParasitology · 2023Article
- Confirmation by necropsy of a high prevalence of porcine cysticercosis in a rural district of Madagascar.Parasitology · 2023Article
- Development and Laboratory Evaluation of a Simple, Field-Applicable Coproantigen Enzyme-Linked Immunosorbent Assay for Diagnosis of Taeniasis in Northern Peru.Journal of clinical microbiology · 2023Article
- CystiHuman: A model of human neurocysticercosis.PLoS computational biology · 2022Article
- Prevalence and factors associated with human Taenia solium taeniosis and cysticercosis in twelve remote villages of Ranomafana rainforest, Madagascar.PLoS neglected tropical diseases · 2022Article
- Practices in research, surveillance and control of neglected tropical diseases by One Health approaches: A survey targeting scientists from French-speaking countries.PLoS neglected tropical diseases · 2021Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 5 countries.
Funding
Abstract
Taenia solium is endemic in Madagascar and presents a significant burden on the population and the health system. The parasite cycles through humans who host the adult tapeworm, and pigs that host the larval stages. Accidental infection of humans may occur with the larval stages which encyst in the nervous central system causing neurocysticercosis, a major cause of seizure disorders and a public health problem. One of the interventions to facilitate the control of the disease is mass drug administration (MDA) of the human population with taeniacide. Here we describe a pilot project conducted in Antanifotsy district of Madagascar from 2015 to 2017 where three annual rounds of MDA (praziquantel, 10mg/Kg) were undertaken in 52 villages. Changes in the prevalence of taeniasis were assessed before, during and after the treatments. A total of 221,308 treatments were given to all eligible people above 5 years of age representing a 95% coverage of the targeted population. No major adverse effects were notified related to the implementation of the MDA. The prevalence of taeniasis was measured using Kato-Katz and copro-antigen techniques. Analyses undertaken combining the results of the Kato-Katz with copro-antigen, or using the Kato-Katz results alone, showed that there was a significant reduction in taeniasis 4 months after the last MDA, but 12 months later (16 months after the last MDA) the taeniasis prevalence had returned to its original levels. Results of the pilot project emphasize the need of a multi-sectorial One-Health approach for the sustained control of T. solium.
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