Evidence map›Paper›PMID 32946280›Full record

ArticleAnnals of the American Thoracic Society2021

Noninvasive Ventilation Use Is Associated with Better Survival in Amyotrophic Lateral Sclerosis.

Jason Ackrivo, Jesse Y Hsu, John Hansen-Flaschen, Lauren Elman, Steven M Kawut

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Annals of the American Thoracic Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07071935 (A Pilot Randomized Clinical Trial of Early Ventilation in Amyotrophic Lateral Sclerosis), which is not on this map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07071935 phase2recruitingnot on this mapstarted 2026, after this paper: background citation

A Pilot Randomized Clinical Trial of Early Ventilation in Amyotrophic Lateral Sclerosis (EVENT ALS)

TypeinterventionalSponsorUniversity of PennsylvaniaRan2026 to 2029Enrolled48ConditionsAmyotrophic Lateral Sclerosis (ALS), Chronic Respiratory Failure, Neuromuscular Disease Patients, Neuromuscular DiseaseArmsNon-invasive ventilation
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.

  1. Pooled it
  2. Exploration of reliable assessment of respiratory function in amyotrophic lateral sclerosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Jason AckrivoDepartment of Medicine.ORCID 0000-0003-4379-1255
Jesse Y HsuDepartment of Biostatistics, Epidemiology and Informatics.ORCID 0000-0002-1522-6534
John Hansen-FlaschenDepartment of Medicine.ORCID 0000-0003-1989-7244
Lauren ElmanDepartment of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0003-4706-950X
Steven M KawutDepartment of Medicine.ORCID 0000-0001-7896-0608
Center for Clinical Research (United States) · USUniversity of Pennsylvania · US

Funding

Cardiology & pulmonary research training grantT32HL007891 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Jason D Christie · 1998 to 2026
$12.0M
Mentored Patient-Oriented Research in Pulmonary Arterial HypertensionK24HL103844 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KAWUT, STEVEN M · 2011 to 2020
$1.6M
Predictors of Respiratory Insufficiency in Amyotrophic Lateral SclerosisF32HL144145 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI ACKRIVO, JASON · 2018 to 2018
$70k
NHLBI NIH HHS F32 HL144145NHLBI NIH HHS K24 HL103844NHLBI NIH HHS T32 HL007891
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Amyotrophic Lateral SclerosisNoninvasive VentilationRespiratory InsufficiencyHumansRetrospective StudiesTime Factorsamyotrophic lateral sclerosismatchingnoninvasive ventilationrespiratory failuresurvival analysis

Identifiers

PMID32946280
PMCPMC7919153
OpenAlexW3087405594

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.