Evidence map›Paper›PMID 32946266›Full record

ArticleAmerican journal of respiratory cell and molecular biology2020

FOXL1 Regulates Lung Fibroblast Function via Multiple Mechanisms.

Naoya Miyashita, Masafumi Horie, Hiroshi I Suzuki, Minako Saito, Yu Mikami, Kenichi Okuda, Richard C Boucher, Maho Suzukawa, Akira Hebisawa, Akira Saito and 1 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
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  5. Tumors and their microenvironments: Learning from pediatric brain pathologies.Biochimica et biophysica acta. Reviews on cancer · 2025
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  12. Lung Transcriptomics Link Emphysema to Barrier Dysfunction and Macrophage Subpopulations.American journal of respiratory and critical care medicine · 2025
    Article
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  14. Review
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  17. Article
  18. Review
  19. DNA methylation modification in Idiopathic pulmonary fibrosis.Frontiers in cell and developmental biology · 2024
    Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Naoya MiyashitaDepartment of Respiratory Medicine, Graduate School of Medicine, and.
Masafumi HorieDepartment of Cancer Genome Informatics, Graduate School of Medicine, Osaka University, Osaka, Japan.
Hiroshi I SuzukiDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Minako SaitoDepartment of Respiratory Medicine, Graduate School of Medicine, and.
Yu MikamiDepartment of Respiratory Medicine, Graduate School of Medicine, and.
Kenichi OkudaDepartment of Respiratory Medicine, Graduate School of Medicine, and.
Richard C BoucherMarsico Lung Institute/Cystic Fibrosis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; and.
Maho SuzukawaNational Hospital Organization Tokyo National Hospital, Tokyo, Japan.
Akira HebisawaNational Hospital Organization Tokyo National Hospital, Tokyo, Japan.
Akira SaitoDepartment of Respiratory Medicine, Graduate School of Medicine, and.ORCID 0000-0002-0184-1376
Takahide NagaseDepartment of Respiratory Medicine, Graduate School of Medicine, and.
Graduate School USA · USUniversity of North Carolina at Chapel Hill · USTokyo National Hospital · JPNagoya University · JPThe University of Osaka · JPThe University of Tokyo · JP

Funding

Vector CoreP30DK065988 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Richard Charles Boucher, Martina Gentzsch · 2004 to 2026
$26.5M
NIDDK NIH HHS P30 DK065988
6 · The paper itself

Abstract

Fibroblasts provide a structural framework for multiple organs and are essential for wound repair and fibrotic processes. Here, we demonstrate functional roles of FOXL1 (forkhead box L1), a transcription factor that characterizes the pulmonary origin of lung fibroblasts. We detected high

Indexed as

Adaptor Proteins, Signal TransducingCell ProliferationFibroblastsFibrosisForkhead Transcription FactorsGene Expression RegulationHumansIdiopathic Pulmonary FibrosisLungAdaptor Proteins, Signal TransducingForkhead Transcription FactorsFOXL1 protein, humancap analysis of gene expressionfibroblastFOXL1idiopathic pulmonary fibrosissuper-enhancer

Identifiers

PMID32946266
PMCPMC8017595
OpenAlexW3087132303

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.