Evidence map›Paper›PMID 32946149›Full record

ReviewReviews in medical virology2021

Covid-19 and dengue: Double punches for dengue-endemic countries in Asia.

Harapan Harapan, Mirza Ryan, Benediktus Yohan, Rufika Shari Abidin, Firzan Nainu, Ahmed Rakib, Israt Jahan, Talha Bin Emran, Irfan Ullah, Kritu Panta and 2 more

Open access · bronzeAbstract readReview
In one paragraph

Review in Reviews in medical virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 1 pooled it
28.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 1 synthesis or guideline pooled it, 192 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Antibody-dependent enhancement of coronaviruses.International journal of biological sciences · 2025
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Potential Way to Develop Dengue Virus Detection inTropical medicine and infectious disease · 2024
    Review
  18. Review
  19. Article
  20. Severe dengue in the intensive care unit.Journal of intensive medicine · 2024
    Review

39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 5 countries.

Harapan HarapanMedical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia.ORCID https://orcid.org/0000-0001-7630-8413
Mirza RyanMedical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia.
Benediktus YohanEijkman Institute for Molecular Biology, Jakarta, Indonesia.
Rufika Shari AbidinFaculty of Medicine, Hasanuddin University, Makassar, Indonesia.
Firzan NainuFaculty of Pharmacy, Hasanuddin University, Makassar, Indonesia.
Ahmed RakibDepartment of Pharmacy, Faculty of Biological Sciences, University of Chittagong, Chittagong, Bangladesh.
Israt JahanDepartment of Pharmacy, International Islamic University Chittagong, Chittagong, Bangladesh.
Talha Bin EmranDepartment of Pharmacy, BGC Trust University Bangladesh, Chittagong, Bangladesh.
Irfan UllahKabir Medical College, Gandhara University, Peshawar, Pakistan.
Kritu PantaSchool of Biomedical Sciences, The University of Western Australia, Crawley, Australia.
Kuldeep DhamaDivision of Pathology, ICAR-Indian Veterinary Research Institute, Bareilly, India.
R Tedjo SasmonoEijkman Institute for Molecular Biology, Jakarta, Indonesia.
Eijkman Institute for Molecular Biology · IDHasanuddin University · IDUniversitas Syiah Kuala · IDBGC Trust University Bangladesh · BDGandhara University · PKIndian Veterinary Research Institute · INInternational Islamic University Chittagong · BDThe University of Western Australia · AUUniversity of Chittagong · BD

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The coronavirus disease 2019 (Covid-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is an international public health crisis with devastating effects. In particular, this pandemic has further exacerbated the burden in tropical and subtropical regions of the world, where dengue fever, caused by dengue virus (DENV), is already endemic to the population. The similar clinical manifestations shared by Covid-19 and dengue fever have raised concerns, especially in dengue-endemic countries with limited resources, leading to diagnostic challenges. In addition, cross-reactivity of the immune responses in these infections is an emerging concern, as pre-existing DENV-antibodies might potentially affect Covid-19 through antibody-dependent enhancement. In this review article, we aimed to raise the issue of Covid-19 and dengue fever misdiagnosis, not only in a clinical setting but also with regards to cross-reactivity between SARS-CoV-2 and DENV antibodies. We also have discussed the potential consequences of overlapping immunological cascades between dengue and Covid-19 on disease severity and vaccine development.

Indexed as

AnimalsAntibodies, ViralAntibody-Dependent EnhancementAsiaCoinfectionCOVID-19DengueDengue VirusHumansPandemicsSARS-CoV-2Antibodies, ViralADECovid-19cross-reactivitydengueSARS-CoV-2

Identifiers

PMID32946149
PMCPMC7536968
OpenAlexW3087604431

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.