Evidence map›Paper›PMID 32946066›Full record

ArticleHuman cell2021

RP11-462C24.1 suppresses proliferation and invasion of colorectal carcinoma cells by regulating HSP70 through PI3K/AKT signaling pathway.

Haiqing Zhang, Guangjun Zhang, Haijun Liu, Yuanzhou Shan, Xueli Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in Human cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Haiqing ZhangDepartment of General Surgery, Affiliated Fengxian Hospital, The Third School of Clinical Medicine, Southern Medical University, 6600 Nanfeng Highway, Shanghai, 201499, China.
Guangjun ZhangDepartment of General Surgery, Affiliated Fengxian Hospital, The Third School of Clinical Medicine, Southern Medical University, 6600 Nanfeng Highway, Shanghai, 201499, China.
Haijun LiuDepartment of General Surgery, Affiliated Fengxian Hospital, The Third School of Clinical Medicine, Southern Medical University, 6600 Nanfeng Highway, Shanghai, 201499, China.
Yuanzhou ShanDepartment of General Surgery, Affiliated Fengxian Hospital, The Third School of Clinical Medicine, Southern Medical University, 6600 Nanfeng Highway, Shanghai, 201499, China.
Xueli ZhangDepartment of General Surgery, Affiliated Fengxian Hospital, The Third School of Clinical Medicine, Southern Medical University, 6600 Nanfeng Highway, Shanghai, 201499, China. lejing1996@hotmail.com.
Southern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colorectal cancer (CRC) is the third leading cause of cancer-related death around the world. In this study, we investigated the roles of LncRNA RP11-462C24.1 in CRC. The expressions of RP11-462C24.1 in CRC tissues and cells were measured. Then, the effects of RP11-462C24.1 on CRC proliferation, cell cycle, apoptosis, and invasion were evaluated both in vivo and in vitro; Last, the underlying mechanisms of concerning the signaling pathway regulated by RP11-462C24.1 was determined. From the results, we found that RP11-462C24.1 was significantly decreased in CRC tumor tissues and the CRC cell lines, which were most significant in SW480 and HT-29 cell lines; moreover, transient overexpression of RP11-462C24.1 suppressed the growth and migration while promoted apoptosis of SW480 and HT-29 cells, while knockdown of RP11-462C24.1 has shown the opposite effects; RP11-462C24.1 may also inhibit the growth of CRC tumors in xenograft mice models; additionally, 70 kD heat shock proteins (HSP70) has been identified as one of the most significantly deferentially expressed genes by RNA-seq, and we further confirmed that RP11-462C24.1 may affect the growth and metathesis of CRC cells via regulating HSP70 and PI3K/AKT signaling pathway. In summary, these results indicated that RP11-462C24 may function as a tumor suppressor in the development of CRC.

Indexed as

Cell Line, TumorCell ProliferationColorectal NeoplasmsGene Expression Regulation, NeoplasticGenes, Tumor SuppressorHSP70 Heat-Shock ProteinsHumansNeoplasm InvasivenessPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRNA, Long NoncodingSignal TransductionHSP70 Heat-Shock ProteinsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRNA, Long NoncodingCRCHSP70LncRNARP11-462C24.1

Identifiers

PMID32946066
OpenAlexW3087371808

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.