ArticleAging clinical and experimental research2020
Delirium in COVID-19: epidemiology and clinical correlations in a large group of patients admitted to an academic hospital.
Article in Aging clinical and experimental research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.
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Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 114 citations in OpenAlex.
- Delirium is a good predictor for poor outcomes from coronavirus disease 2019 (COVID-19) pneumonia: A systematic review, meta-analysis, and meta-regression.Journal of psychiatric research · 2021Pooled it
- Delirium and Mortality in Coronavirus Disease 2019 (COVID-19) - A Systematic Review and Meta-analysis.Archives of gerontology and geriatricsPooled it
- Recent developments of vaccines for older adults: Adjuvants and beyond.Human vaccines & immunotherapeutics · 2025Review
- Trends and Mortality Predictors of Delirium Among Hospitalized Older Adults: A National 5-Year Retrospective Study in Thailand.Geriatrics (Basel, Switzerland) · 2025Article
- Associations between metabolomic scores and clinical outcomes in hospitalized COVID-19 patients.GeroScience · 2025Article
- [Atypical clinical and mortality in older adults hospitalized with COVID-19 pneumonia].Revista medica del Instituto Mexicano del Seguro Social · 2025Observational
- In-Hospital Delirium and Disability and Cognitive Impairment After COVID-19 Hospitalization.JAMA network open · 2024Article
- Factors associated with delirium in a real-world acute-care setting: analysis considering the interdependence of clinical variables with the frailty syndrome.European geriatric medicine · 2024Article
- Use of a Data Repository to Identify Delirium as a Presenting Symptom of COVID-19 Infection in Hospitalized Adults: Cross-Sectional Cohort Pilot Study.JMIR aging · 2023Article
- Delirium in hospitalized COVID-19 patients: a prospective, multicenter, cohort study.Journal of neurology · 2023Article
- Association of Delirium and Depression with Respiratory and Outcome Measures in COVID-19 Inpatients.Journal of personalized medicine · 2023Article
- Incidence Rate and Factors Associated with Delirium and Subsyndromal Delirium in Patients with COVID-19 in an Intensive Care Unit.Journal of clinical medicine · 2023Article
- Survey of psychiatric symptoms among inpatients with COVID-19 using the Diagnosis Procedure Combination data and medical records in Japan.Brain, behavior, & immunity - health · 2023Article
- Frequency of delirium and its associated factors among COVID-19 inpatients in Iran.The clinical respiratory journal · 2023Article
- Investigating nurses' knowledge and attitudes about delirium in older persons: a cross-sectional study.BMC nursing · 2023Article
- The possible role of gut microbiota dysbiosis in the pathophysiology of delirium in older persons.Microbiome research reports · 2023Review
- Nomogram to predict the incidence of delirium in elderly patients with non-severe SARS-CoV-2 infection.Frontiers in psychiatry · 2023Article
- Delirium in a Relatively Young Person due to COVID-19 Infection.Case reports in psychiatry · 2023Article
- Common Biomarkers Associated with Delirium in Hospitalized Patients with COVID-19 at the Epicentre of Turkish Coronavirus Outbreak: A Case-Control Study.Noro psikiyatri arsivi · 2023Article
- Restraint Practices in Incapable Wandering Patients During COVID-19: Ethics and Best Practice Recommendations.Canadian geriatrics journal : CGJ · 2022Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDelirium incidence and clinical correlates in coronavirus disease-19 (COVID-19) pneumonia are still poorly investigated.
aimTo describe the epidemiology of delirium in patients hospitalized for suspect COVID-19 pneumonia during the pandemic peak in an academic hospital of Northern Italy, identify its clinical correlations and evaluate the association with mortality.
methodsThe clinical records of 852 patients admitted for suspect COVID-19 pneumonia, defined as respiratory symptoms or fever or certain history of contact with COVID-19 patients, plus chest CT imaging compatible with alveolar-interstitial pneumonia, were retrospectively analyzed. Delirium was defined after careful revision of daily clinical reports in accordance with the Confusion Assessment Method criteria. Data on age, clinical presentation, comorbidities, drugs, baseline lab tests and outcome were collected. The factors associated with delirium, and the association of delirium with mortality, were evaluated through binary logistic regression models.
resultsNinety-four patients (11%) developed delirium during stay. They were older (median age 82, interquartile range, IQR 78-89, vs 75, IQR 63-84, p < 0.001), had more neuropsychiatric comorbidities and worse respiratory exchanges at baseline. At multivariate models, delirium was independently and positively associated with age [odds ratio (OR) 1.093, 95% confidence interval (CI) 1.046-1.143, p < 0.001], use of antipsychotic drugs (OR 4.529, 95% CI 1.204-17.027, p = 0.025), serum urea and lactate-dehydrogenase at admission. Despite a higher mortality in patients with delirium (57% vs 30%), this association was not independent of age and respiratory parameters.
conclusionsDelirium represents a common complication of COVID-19 and a marker of severe disease course, especially in older patients with neuropsychiatric comorbidity.
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