Evidence map›Paper›PMID 32945916›Full record

ReviewDer Pathologe2020

[Quality assurance in diagnostic in situ hybridization-experience of QuIP].

Korinna Jöhrens, Reinhard von Wasielewski, Hans-H Kreipe, Almuth Forberger, Philipp Jurmeister, Manfred Dietel, Albrecht Stenzinger, Josephine Fischer

Abstract readReview
PubMed Publisher
In one paragraph

Review in Der Pathologe, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Korinna JöhrensInstitut für Pathologie, Universitätsklinikum Carl Gustav Carus, TU Dresden, Dresden, Deutschland. Korinna.Joehrens@uniklinikum-dresden.de.
Reinhard von WasielewskiMVZ Pathologie Hildesheim Hannover-Zentrum GmbH, Hildesheim, Deutschland.
Hans-H KreipeInstitut für Pathologie, Medizinische Hochschule Hannover, Hannover, Deutschland.
Almuth ForbergerInstitut für Pathologie, Universitätsklinikum Carl Gustav Carus, TU Dresden, Dresden, Deutschland.
Philipp JurmeisterInstitut für Pathologie, Universitätsklinikum Charité Berlin, Berlin, Deutschland.
Manfred DietelQualitätssicherungs-Initiative Pathologie QuIP GmbH, Berlin, Deutschland.
Albrecht StenzingerInstitut für Allgemeine Pathologie und Pathologische Anatomie, Universitätsklinikum Heidelberg, Heidelberg, Deutschland.
Josephine FischerQualitätssicherungs-Initiative Pathologie QuIP GmbH, Berlin, Deutschland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Quality Assurance Initiative Pathology (QuIP) gives pathologists the opportunity to check the methodological processes of immunohistological and molecular diagnostics in a result-oriented manner and obtain a certificate reflecting the quality. For in situ hybridization (ISH), 5 round robin tests were organized in 2019, two recurrent (HER2-ISH gastric carcinomas and HER2-ISH breast carcinomas) and three prototypical (ROS1-NSCLC, ALK1-NSCLC, NTRK). The different round robin tests, which were provided by QuIP, are based on the development in diagnostics and the importance of the therapeutic relevance of the molecules which are tested. The results of the round robin tests in 2019 showed a sensitivity of at least 94.4%, a specificity of at least 96.6%, and a success rate of 85-99%. This reflected the high standard of quality of the round robin test and the participating institutes.

Indexed as

Quality Assurance, Health CareBiomarkers, TumorBreast NeoplasmsErb-b2 Receptor Tyrosine KinasesHumansIn Situ HybridizationProto-Oncogene ProteinsSensitivity and SpecificityBiomarkers, TumorErb-b2 Receptor Tyrosine KinasesProto-Oncogene ProteinsISHQuality Assurance Initiative PathologyRobin round testSensitivitySpecificity

Identifiers

PMID32945916

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.