Evidence map›Paper›PMID 32945898›Full record

Trial reportDiabetologia2020

Insulin resistance induced by growth hormone is linked to lipolysis and associated with suppressed pyruvate dehydrogenase activity in skeletal muscle: a 2 × 2 factorial, randomised, crossover study in human individuals.

Astrid J Hjelholt, Evelina Charidemou, Julian L Griffin, Steen B Pedersen, Anders Gudiksen, Henriette Pilegaard, Niels Jessen, Niels Møller, Jens O L Jørgensen

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Diabetologia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02782208 (Lipolytic Effects of GH in Hypopituitary Patients in Vivo), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02782208 nacompletednot on this map

Lipolytic Effects of GH in Hypopituitary Patients in Vivo: Molecular Mechanisms and Temporal Patterns.

TypeinterventionalSponsorUniversity of AarhusRan2016 to 2016Enrolled9ConditionsHypopituitarism, Insulin Resistance, Endocrine System Diseases, Glucose Metabolism DisordersArmsAcipimox, Placebo, GH substitution, GH pause
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Effects of Anterior Pituitary Adenomas' Hormones on Glucose Metabolism and Its Clinical Implications.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023
    Review
  8. Review
  9. Growth Hormone and Insulin-Like Growth Factor 1 Regulation of Nonalcoholic Fatty Liver Disease.The Journal of clinical endocrinology and metabolism · 2022 · on this map
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Astrid J HjelholtMedical Research Laboratory, Department of Clinical Medicine, Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus N, Denmark. ajh@clin.au.dk.ORCID 0000-0002-3114-4176
Evelina CharidemouDepartment of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK.ORCID 0000-0002-2299-9471
Julian L GriffinDepartment of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK.ORCID 0000-0003-1336-7744
Steen B PedersenMedical Research Laboratory, Department of Clinical Medicine, Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus N, Denmark.ORCID 0000-0002-7838-8063
Anders GudiksenSection for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-1800-4838
Henriette PilegaardSection for Cell Biology and Physiology, Department of Biology, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-1071-0327
Niels JessenDepartment of Clinical Pharmacology, Aarhus University Hospital, Aarhus C, Denmark.ORCID 0000-0001-5613-7274
Niels MøllerMedical Research Laboratory, Department of Clinical Medicine, Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus N, Denmark.ORCID 0000-0001-5627-7322
Jens O L JørgensenMedical Research Laboratory, Department of Clinical Medicine, Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus N, Denmark.ORCID 0000-0001-7408-1526
Aarhus University Hospital · DKUniversity of Cambridge · GBUniversity of Copenhagen · DKAarhus University · DK

Funding

Medical Research Council MC_PC_13030Medical Research Council MC_UP_A090_1006Medical Research Council MR/P011705/1Medical Research Council MR/P01836X/1
6 · The paper itself

Abstract

aims/hypothesisGrowth hormone (GH) causes insulin resistance that is linked to lipolysis, but the underlying mechanisms are unclear. We investigated if GH-induced insulin resistance in skeletal muscle involves accumulation of diacylglycerol (DAG) and ceramide as well as impaired insulin signalling, or substrate competition between fatty acids and glucose.

methodsNine GH-deficient male participants were randomised and examined in a 2 × 2 factorial design with and without administration of GH and acipimox (an anti-lipolytic compound). As-treated analyses were performed, wherefore data from three visits from two patients were excluded due to incorrect GH administration. The primary outcome was insulin sensitivity, expressed as the AUC of the glucose infusion rate (GIR

resultsCo-administration of acipimox completely suppressed the GH-induced elevation in serum levels of NEFA (GH versus GH+acipimox, p < 0.0001) and abrogated GH-induced insulin resistance (mean GIR CONCLUSIONS/

interpretationGH-induced insulin resistance in skeletal muscle is: (1) causally linked to lipolysis; (2) not associated with either accumulation of DAGs and ceramides or impaired insulin signalling; (3) likely to involve substrate competition between glucose and lipid intermediates.

trial registrationClinicalTrials.gov NCT02782208

fundingThe work was supported by the Grant for Growth Innovation (GGI), which was funded by Merck KGaA, Darmstadt, Germany. Graphical abstract.

Indexed as

Calorimetry, IndirectCeramidesDiglyceridesElectrophoresis, CapillaryGrowth HormoneHumansInsulin ResistanceLipid MetabolismLipolysisMaleMuscle, SkeletalPolymerase Chain ReactionPyrazinesPyruvate Dehydrogenase ComplexacipimoxCeramidesDiglyceridesGrowth HormonePyrazinesPyruvate Dehydrogenase ComplexAcipimoxCeramidesDiacylglycerolsFatty acidsGrowth hormoneInsulin resistanceInsulin signallingPyruvate dehydrogenase activity

Identifiers

PMID32945898
OpenAlexW3087636729

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.