ArticleAdvances in nutrition (Bethesda, Md.)2021
Quality of the Evidence Supporting the Role of Oral Nutritional Supplements in the Management of Malnutrition: An Overview of Systematic Reviews and Meta-Analyses.
Article in Advances in nutrition (Bethesda, Md.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Effectiveness of dietary counseling with or without nutrition supplementation in hospitalized patients who are malnourished or at risk of malnutrition: A systematic review and meta-analysis.JPEN. Journal of parenteral and enteral nutrition · 2022Pooled it
- Dietary advice with or without oral nutritional supplements for disease-related malnutrition in adults.The Cochrane database of systematic reviews · 2021Pooled it
- Trial
- Nutrition education with or without oral nutrition supplements has contrasting effects on nutrition status in older adults: A randomized controlled study.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2023Trial
- Assessment of Hospitalized Patients' Awareness Regarding Food for Special Medical Purposes.Nutrients · 2026Article
- Pharmacological intervention: Challenges and promising outcomes for fat loss and preservation of lean body mass in the treatment of overweight and type 2 diabetes.Diabetes, obesity & metabolism · 2026Review
- Early combined parenteral and enteral nutrition support for patients over 80 years old with non-operative intestinal obstruction.Frontiers in nutrition · 2026Article
- Cost-Effectiveness of Oral Nutritional Supplements in Malnourished or at Risk of Disease-Related Malnutrition Cancer Patients in North Macedonia.ClinicoEconomics and outcomes research : CEOR · 2025Article
- Strategies for minimizing muscle loss during use of incretin-mimetic drugs for treatment of obesity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Review
- A Cost-Consequence Analysis of Nutritional Interventions Used in Hospital Settings for Older Adults with or at Risk of Malnutrition.Healthcare (Basel, Switzerland) · 2024Article
- A Conceptual Study on Characterizing the Complexity of Nutritional Interventions for Malnourished Older Adults in Hospital Settings: An Umbrella Review Approach.Healthcare (Basel, Switzerland) · 2024Article
- Article
- Recommending ultra-processed oral nutrition supplements for unintentional weight loss: Are there risks?Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2023Review
- Improving the assessment of older adult's nutrition in primary care: recommendations for a proactive, patient-centred and aetiology approach.BMJ nutrition, prevention & health · 2023Article
- The application of the county medical community HCH model in postoperative nutrition management for patients with advanced gastrointestinal carcinoma.American journal of translational research · 2023Article
- Adequacy of Nutritional Intakes during the Year after Critical Illness: An Observational Study in a Post-ICU Follow-Up Clinic.Nutrients · 2022Observational
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is considerable heterogeneity across the findings of systematic reviews of oral nutritional supplement (ONS) interventions, presenting difficulties for healthcare decision-makers and patients alike. It is not known whether heterogeneity arises from differences in patient populations or relates to methodological rigor. This overview aimed to collate and compare findings from systematic reviews of ONSs compared with routine care in adult patients who were malnourished or at risk of malnutrition with any clinical condition and to examine their methodological quality. Three electronic databases were searched to July 2019, supplemented with hand-searching. Data on all outcomes were extracted and review methodological quality assessed using A MeaSurement Tool for Assessment of systematic Reviews (AMSTAR). Twenty-two reviews were included, 11 in groups from mixed clinical backgrounds and 11 in specific clinical conditions. Ninety-one meta-analyses were identified for 12 different outcomes but there was discordance between results. Significant benefits of ONSs were reported in 4 of 4 analyses of energy intake, 7 of 11 analyses of body weight, 7 of 22 analyses of mortality, 10 of 17 analyses of complications (total and infectious), 1 of 3 analyses of muscle strength, 4 of 9 analyses of body composition/nutritional status, 2 of 14 analyses of length of stay, and 2 of 5 analyses of hospital readmissions. Ten reviews were high quality (AMSTAR scores 8-11), 9 moderate (AMSTAR scores 3-8), and 3 poor (AMSTAR scores 0-3). Methodological deficiencies were limitations to searches, poor reporting of heterogeneity, and failure to incorporate quality of evidence into any recommendations. Discordance between reviews was not markedly reduced when only high-quality reviews were considered. Evidence for the effects of ONS in malnourished patients or those who are at risk of malnutrition is uncertain, and discordance in results can arise from differences in clinical background of patients or the etiological basis of malnutrition.
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