Evidence map›Paper›PMID 32945820›Full record

ArticleChemical communications (Cambridge, England)2020

Leveraging synthetic chlorins for bio-imaging applications.

Javier Hernández-Gil, Jason S Lewis, Thomas Reiner, Charles Michael Drain, Junior Gonzales

Open access · greenAbstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. NabioRxiv : the preprint server for biology · 2024
    Article
  2. Development and Validation of Nerve-Targeted Bacteriochlorin Sensors.Journal of the American Chemical Society · 2023
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Javier Hernández-GilDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. gonzalj4@mskcc.org and Biomedical MRI/MoSAIC, Department of Imaging and Pathology, Katholieke Universiteit Leuven, Herestraat 49, B3000, Leuven, Belgium.ORCID http://orcid.org/0000-0002-6177-1971
Jason S LewisDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. gonzalj4@mskcc.org and Weill-Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA and Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.ORCID http://orcid.org/0000-0001-7065-4534
Thomas ReinerDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. gonzalj4@mskcc.org and Weill-Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA and Chemical Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.ORCID http://orcid.org/0000-0002-7819-5480
Charles Michael DrainDepartment of Chemistry, Hunter College of The City University of New York, 695 Park Avenue, New York, NY 10065, USA.ORCID http://orcid.org/0000-0003-2541-2813
Junior GonzalesDepartment of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA. gonzalj4@mskcc.org and Department of Chemistry, Hunter College of The City University of New York, 695 Park Avenue, New York, NY 10065, USA.ORCID http://orcid.org/0000-0002-2266-7565
Memorial Sloan Kettering Cancer Center · USCity University of New York · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Leveraging Pb-203/212 for the Theranostic Imaging and Therapy of Prostate CancerR35CA232130 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S. · 2019 to 2025
$8.2M
Radioiodinated Multifunctional PARP1 Imaging Probes for Diagnosis and TherapyR01CA204441 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI PILLARSETTY, NAGAVARAKISHORE · 2016 to 2020
$2.9M
Development and validation of an intraoperative imaging agent for the peripheral nervous systemR01EB029769 · NIBIB · SLOAN-KETTERING INST CAN RESEARCH · PI PILLARSETTY, NAGAVARAKISHORE · 2020 to 2023
$2.2M
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA204441NCI NIH HHS R35 CA232130NIBIB NIH HHS R01 EB029769
6 · The paper itself

Abstract

Synthetic chlorins are not only fluorescent, the modulation of the tetrapyrrole system can also chelate metal ions. Conjugation of linkers at their pyrrolidines allows for conjugation to bio-molecules to create target specificity. By altering these chemo-photophysical properties, this work facilitates the use of chlorins in fluorescent imaging and positron emission tomography (PET).

Indexed as

Microscopy, FluorescenceCell Line, TumorCoordination ComplexesHumansMetalsNeoplasmsPorphyrinsPositron-Emission TomographyPyrrolidinesCoordination ComplexesMetalsPorphyrinsPyrrolidines

Identifiers

PMID32945820
PMCPMC7907923
OpenAlexW3083951171

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.