ArticleImmunology1987
Sialadenitis in the MRL-l mouse: morphological and immunohistochemical characterization of resident and infiltrating cells.
Article in Immunology, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 94 citations in OpenAlex.
- Animal models of dry eye: Their strengths and limitations for studying human dry eye disease.Journal of the Chinese Medical Association : JCMA · 2021Article
- Stimulation of regulatory T cells with Lactococcus lactis expressing enterotoxigenic E. coli colonization factor antigen 1 retains salivary flow in a genetic model of Sjögren's syndrome.Arthritis research & therapy · 2021Article
- Therapeutic Potential of Anti-Interferon α Vaccination on SjS-Related Features in the MRL/lpr Autoimmune Mouse Model.Frontiers in immunology · 2021Article
- Prdm1 Regulates Thymic Epithelial Function To Prevent Autoimmunity.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- A Chronic Autoimmune Dry Eye Rat Model with Increase in Effector Memory T Cells in Eyeball Tissue.Journal of visualized experiments : JoVE · 2017Article
- The value of animal models to study immunopathology of primary human Sjögren's syndrome symptoms.Expert review of clinical immunology · 2014Review
- Mutation of POLB causes lupus in mice.Cell reports · 2014Article
- Loss of PKCδ results in characteristics of Sjögren's syndrome including salivary gland dysfunction.Oral diseases · 2011Article
- Sjögren's syndrome: studying the disease in mice.Arthritis research & therapy · 2011Review
- Current concepts: mouse models of Sjögren's syndrome.Journal of biomedicine & biotechnology · 2011Review
- Impaired vascular responses to parasympathetic nerve stimulation and muscarinic receptor activation in the submandibular gland in nonobese diabetic mice.Arthritis research & therapy · 2009Article
- Unraveling the pathophysiology of Sjogren syndrome-associated dry eye disease.The ocular surface · 2009Review
- Blockade of lymphotoxin-beta receptor signaling reduces aspects of Sjögren's syndrome in salivary glands of non-obese diabetic mice.Arthritis research & therapy · 2009Article
- Autoimmune Th2-mediated dacryoadenitis in MRL/MpJ mice becomes Th1-mediated in IL-4 deficient MRL/MpJ mice.Investigative ophthalmology & visual science · 2007Article
- Animal models of Sjögren's syndrome.Clinical reviews in allergy & immunology · 2007Review
- The influence of the NOD Nss1/Idd5 loci on sialadenitis and gene expression in salivary glands of congenic mice.Arthritis research & therapy · 2007Article
- Use of localised gene transfer to develop new treatment strategies for the salivary component of Sjögren's syndrome.Annals of the rheumatic diseases · 2003Review
- The transmembrane form of TNF-alpha drives autoantibody production in the absence of CD154: studies using MRL/Mp-Fas(lpr) mice.Clinical and experimental immunology · 2002Article
- Tamoxifen alleviates disease severity and decreases double negative T cells in autoimmune MRL-lpr/lpr mice.Immunology · 2000Article
- Estrogen deficiency accelerates autoimmune exocrinopathy in murine Sjögren's syndrome through fas-mediated apoptosis.The American journal of pathology · 1999Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The MRL-lpr/lpr (MRL/l) mouse spontaneously develops an autoimmune disease associated with various rheumatic manifestations. We have studied the histological features of sialadenitis and utilized an immunohistochemical staining technique on frozen tissue sections to analyse the cellular composition of the salivary glands at varying stages of disease. Semiquantitative assessment of the infiltration disclosed a focal inflammation which started at 2 months of age and was progressive until 5 months of age in submandibular glands. A high frequency of Ly-1 and L3T4-positive cells was observed at all stages of sialadenitis, whereas Lyt-2 positive cells were found at a lower frequency. Ia expression was seen on a large proportion of the infiltrating cells and also on ductal and glandular epithelial cells in the vicinity of the inflammatory lesions. The presence of Ia antigens on many inflammatory as well as resident cells and the high frequency of lymphocytes with 'helper' phenotype may indicate a perpetuated immunological activation within salivary glands.
Indexed as
Identifiers
3294576PMC1453282W2398161402What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.