ArticleMolecular medicine reports2020
Competing endogenous RNA network analysis for screening inflammation‑related long non‑coding RNAs for acute ischemic stroke.
Article in Molecular medicine reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Multiomic integration analysis identifies atherogenic metabolites mediating between novel immune genes and cardiovascular risk.Genome medicine · 2024Pooled it
- Antisense Transcription in Plants: A Systematic Review and an Update on cis-NATs of Sugarcane.International journal of molecular sciences · 2022Pooled it
- NLRP3 Regulation in Neonatal Hypoxic-Ischemic Encephalopathy-Focus on Microglial Activation.International journal of molecular sciences · 2026Article
- Attenuation of sepsis-associated acute lung injury by lncRNA LINC00052 via sponging miR-106b-5p.Journal of cardiothoracic surgery · 2026Article
- Silencing LncRNA HCG27 ameliorates cognitive dysfunction after ischemic stroke via miR-27a-3p regulation.Hereditas · 2025Article
- Regulatory Roles of Long Noncoding RNAs in Arterial Stiffness and Hypertension.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Complement inhibition targets a rich-club within the neuroinflammatory network after stroke to improve radiographic and functional outcomes.Journal of neuroinflammation · 2025Article
- Direct and indirect role of non-coding RNAs in company with amyloid and tau protein in promoting neuroinflammation in post-ischemic brain neurodegeneration.Frontiers in cellular neuroscience · 2025Review
- Role of transcription factors, noncoding RNAs, epitranscriptomics, and epigenetics in post-ischemic neuroinflammation.Journal of neurochemistry · 2024Review
- Diagnostic and Predictive Value of LncRNA MCM3AP-AS1 in Sepsis and Its Regulatory Role in Sepsis-Induced Myocardial Dysfunction.Cardiovascular toxicology · 2024Article
- Regulatory Roles of Long Non-Coding RNAs in Arterial Stiffness and Hypertension: Insights from Two African American Studies.bioRxiv : the preprint server for biology · 2024Article
- Molecular subtype identification of cerebral ischemic stroke based on ferroptosis-related genes.Scientific reports · 2024Article
- Expression levels and clinical significance of serum miR-19a/CCL20 in patients with acute cerebral infarction.Open medicine (Warsaw, Poland) · 2024Article
- Article
- Competing endogenous RNA network analysis of the molecular mechanisms of ischemic stroke.BMC genomics · 2023Article
- Identifying potential therapeutic targets for ischemic stroke through immune infiltration analysis and construction of a programmed cell death‑related ceRNA network.Experimental and therapeutic medicine · 2022Article
- Is Immune Suppression Involved in the Ischemic Stroke? A Study Based on Computational Biology.Frontiers in aging neuroscience · 2022Article
- Long Non-Coding RNA MCM3AP-AS1: A Crucial Role in Human Malignancies.Pathology oncology research : POR · 2022Review
- Integrated Analysis of Competitive Endogenous RNA Networks in Acute Ischemic Stroke.Frontiers in genetics · 2022Article
- Noncoding RNA crosstalk in brain health and diseases.Neurochemistry international · 2021Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long non‑coding RNAs (lncRNAs) represent potential biomarkers for the diagnosis and treatment of various diseases; however, the role of circulating acute ischemic stroke (AIS)‑related lncRNAs remains relatively unknown. The present study aimed to screen crucial lncRNAs for AIS based on the competing endogenous RNA (ceRNA) hypothesis. The expression profile datasets for one mRNA, accession no. GSE16561, and four microRNAs (miRNAs), accession nos. GSE95204, GSE86291, GSE55937 and GSE110993, were downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs), lncRNAs (DELs), and miRNAs (DEMs) were identified, and ClusterProfiler was used to interpret the function of the DEGs. Based on the protein‑protein interaction (PPI) network and module analyses, hub DEGs were identified. A ceRNA network was established based on miRNA‑mRNA or miRNA‑lncRNA interaction pairs. In total, 2,041 DEGs and 5 DELs were identified between the AIS and controls samples in GSE16561, and 10 DEMs between at least two of the four miRNA expression profiles. A PPI network was constructed with 1,235 DEGs, among which 20 genes were suggested to be hub genes. The hub genes paxillin (PXN), FYN‑proto‑oncogene, Src family tyrosine kinase (FYN), ras homolog family member A (RHOA), STAT1, and growth factor receptor‑bound protein 2 (GRB2), were amongst the most significantly enriched modules extracted from the PPI network. Functional analysis revealed that these hub genes were associated with inflammation‑related signaling pathways. An AIS‑related ceRNA network was constructed, in which 4 DELs were predicted to function as ceRNAs for 9 DEMs, to regulate the five identified hub genes; that is, minichromosome maintenance complex component 3 associated protein‑antisense RNA 1 (MCM3AP‑AS1)/long intergenic non‑protein coding RNA 1089 (LINC01089)/hsa‑miRNA (miR)‑125a/FYN, inositol‑tetrakisphosphate 1‑kinase‑antisense RNA 1 (ITPK1‑AS1)/hsa‑let‑7i/RHOA/GRB2/STAT1, and human leukocyte antigen complex group 27 (HCG27)/hsa‑-miR‑19a/PXN interaction axes. In conclusion, MCM3AP‑AS1, LINC01089, ITPK1‑AS1, and HCG27 may represent new biomarkers and underlying targets for the treatment of AIS.
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