ArticleMolecular medicine reports2020
Effect of ultra‑wide‑band electromagnetic pulses on blood‑brain barrier permeability in rats.
Article in Molecular medicine reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- Transient biological response of human mesenchymal stem cells to a single wideband high-power electromagnetic pulse exposure: a preliminary study.Frontiers in cell and developmental biology · 2026Article
- Alterations in the Temporal Variation and Spatial Distribution of Blood-Brain Barrier Permeability Following Electromagnetic Pulse Radiation: A Study Based on Dynamic Contrast-Enhanced MRI.Brain sciences · 2025Article
- Review
- Combined effects of EMP and RF field on emotional behavior in mice.Frontiers in public health · 2023Article
- Lipid Peroxides Mediated Ferroptosis in Electromagnetic Pulse-Induced Hippocampal Neuronal Damage via Inhibition of GSH/GPX4 Axis.International journal of molecular sciences · 2022Article
- High-Power Electromagnetic Pulse Exposure of Healthy Mice: Assessment of Effects on Mice Cognitions, Neuronal Activities, and Hippocampal Structures.Frontiers in cellular neuroscience · 2022Article
- Regulation of pathological blood-brain barrier for intracranial enhanced drug delivery and anti-glioblastoma therapeutics.Oncology research · 2021Review
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The restrictive nature of the blood brain barrier (BBB) brings a particular challenge to the treatment of central nervous system (CNS) disorders. The effect of ultra‑wide band electromagnetic pulses (UWB‑EMPs) on BBB permeability was examined in the present study in order to develop a safe and effective technology that opens the BBB to improve treatment options for CNS diseases. Rats were exposed to a single UWB‑EMP at various field strengths (50, 200 or 400 kV/m) and the BBB was examined using albumin immunohistochemistry and Evans blue staining at different time periods (0.5, 3, 6 and 24 h) after exposure. The expression and distribution of zonula occludens 1 (ZO‑1) were evaluated using western blotting to identify a potential mechanism underlying BBB permeability. The results showed that the BBB permeability of rats exposed to UWB‑EMP increased immediately following UWM‑EMP treatment and peaked between 3 and 6 h after UWB‑EMP exposure, returning to pre‑exposure levels 24 h later. The data suggested that UWB‑EMP at 200 and 400 kV/m could induce BBB opening, while 50 kV/m UWB‑EMP could not. The levels of ZO‑1 in the cerebral cortex were significantly decreased at 3 and 6 h after exposure; however, no change was observed in the distribution of ZO‑1. The present study indicated that UWB‑EMP‑induced BBB opening was field strength‑dependent and reversible. Decreased expression of ZO‑1 may be involved in the effect of UWB‑EMP on BBB permeability.
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