ArticleAdvanced materials (Deerfield Beach, Fla.)2020
An Adhesive Hydrogel with "Load-Sharing" Effect as Tissue Bandages for Drug and Cell Delivery.
Article in Advanced materials (Deerfield Beach, Fla.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 204 citations in OpenAlex.
- Design, Properties and Applications of Multiple Dynamic Hydrogels.Materials (Basel, Switzerland) · 2026Review
- Biomimetic interfacial water-regulated hybrid dual-layer hydrogel for wound healing, anti-adhesion and hemostasis post partial hepatectomy.Materials today. Bio · 2026Article
- Tissue-bioelectronics interfaces.Chemical Society reviews · 2026Review
- Hydrogel Adhesives for Gastrointestinal Perforation: Design Principles and Applications.Exploration (Beijing, China) · 2026Review
- Spermidine-functionalized Janus hydrogel microneedles inhibit ferroptosis and promote healing of oral ulcers.Bioactive materials · 2026Article
- Recent Progress and Morphological Distribution of Polydopamine-Based Biomaterials and Their Applications.Gels (Basel, Switzerland) · 2026Review
- A dynamically adaptive wet-adhesive Janus hydrogel patch for sutureless repair of spinal dural defects.Bioactive materials · 2026Article
- Universal Method for Covalent Attachment of Hydrogels to Diverse Polymeric Surfaces for Biomedical Applications.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- A dual-component particulate dressing for simultaneous microenvironment modulation and tissue regeneration in infected diabetic wounds.Materials today. Bio · 2025Article
- Magnetic nanostickers for active control of interface-enhanced selective bioadhesion.Nature communications · 2025Article
- Multi-targeted nanogel drug delivery system alleviates neuroinflammation and promotes spinal cord injury repair.Materials today. Bio · 2025Article
- Degradable polymer bone adhesives.Fundamental research · 2025Review
- Preventing postsurgical colorectal cancer relapse: A hemostatic hydrogel loaded with METTL3 inhibitor for CAR-NK cell therapy.Bioactive materials · 2025Article
- Octopus-Inspired Adhesives with Switchable Attachment to Challenging Underwater Surfaces.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A Janus hydrogel that enables wet tissue adhesion and resists abdominal adhesions.Materials today. Bio · 2024Article
- Overview of Dynamic Bond Based Hydrogels for Reversible Adhesion Processes.Gels (Basel, Switzerland) · 2024Review
- Functional hydrogels for hepatocellular carcinoma: therapy, imaging, and in vitro model.Journal of nanobiotechnology · 2024Review
- Emerging approaches for the development of artificial islets.Smart medicine · 2024Review
- A low-swelling hydrogel as a multirole sealant for efficient dural defect sealing and prevention of postoperative adhesion.National science review · 2024Article
- Swim bladder-derived biomaterials: structures, compositions, properties, modifications, and biomedical applications.Journal of nanobiotechnology · 2024Review
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
Hydrogels with adhesive properties have potential for numerous biomedical applications. Here, the design of a novel, intrinsically adhesive hydrogel and its use in developing internal therapeutic bandages is reported. The design involves incorporation of "triple hydrogen bonding clusters" (THBCs) as side groups into the hydrogel matrix. The THBC through a unique "load sharing" effect and an increase in bond density results in strong adhesions of the hydrogel to a range of surfaces, including glass, plastic, wood, poly(tetrafluoroethylene) (PTFE), stainless steel, and biological tissues, even without any chemical reaction. Using the adhesive hydrogel, tissue-adhesive bandages are developed for either targeted and sustained release of chemotherapeutic nanodrug for liver cancer treatment, or anchored delivery of pancreatic islets for a potential type 1 diabetes (T1D) cell replacement therapy. Stable adhesion of the bandage inside the body enables almost complete tumor suppression in an orthotopic liver cancer mouse model and ≈1 month diabetes correction in chemically induced diabetic mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.