ArticleInternational urology and nephrology2021
Sex disparities in IgA nephropathy: a retrospective study in Chinese patients.
Article in International urology and nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Is hyperuricemia an independent prognostic factor for IgA nephropathy: a systematic review and meta-analysis of observational cohort studies.Renal failure · 2022Pooled it
- Prognosis and predictive factors in pediatric IgA nephropathy.Pediatric nephrology (Berlin, Germany) · 2026Article
- Causal relationship between gastroesophageal reflux disease and IgA nephropathy: a Mendelian randomization analysis.Renal failure · 2025Article
- Sex Differences Across Corticosteroid Response and Outcomes in IgA Nephropathy.Kidney international reports · 2025Article
- LncRNAs and IgA nephropathy: underlying molecular pathways and clinical applications.Clinical and experimental medicine · 2025Review
- Review on epidemiology, disease burden, and treatment patterns of IgA nephropathy in select APAC countries.BMC nephrology · 2024Review
- The causal effect of triglyceride and high blood pressure on IgA nephropathy: a Mendelian randomization study.Frontiers in medicine · 2024Article
- Activation of GPER1 in macrophages ameliorates UUO-induced renal fibrosis.Cell death & disease · 2023Article
- Long-term follow-up of IgA nephropathy: clinicopathological features and predictors of outcomes.Clinical kidney journal · 2023Article
- Validation of two IgA nephropathy risk-prediction tools using a cohort with a long follow-up.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023Article
- Noninvasive evaluation of IgA nephropathy fibrosis using Doppler ultrasound.Renal failure · 2022Article
- Clinicopathological characteristics and risk factors in elderly patients with biopsy-proven IgA nephropathy.Renal failure · 2022Article
- Relationship between Traditional Chinese Medicine Syndrome Elements and Prognosis of Patients with IgA Nephropathy.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Immunoglobulin A (IgA) Nephropathy: A Clinicopathologic Study in a Tertiary Care Center in Saudi Arabia.Cureus · 2021Article
- Association between urinary VEGFA and renal pathology of IgA nephropathy patients.Journal of clinical laboratory analysis · 2021Article
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Authors and funding
7 authors.
Funding
Abstract
aimThe aim of this study was to explore the effect of sex on the clinicopathological features and long-term outcomes of IgAN patients.
methodsA total of 1096 adult IgAN patients were divided into male and female groups. Clinicopathological features and risk factors of IgAN patients of different genders were contrasted. The primary endpoint was the combined endpoint of a 50% reduction in estimated glomerular filtration rate (eGFR) and/or end stage renal disease (ESRD: eGFR < 15 mL/min/1.73 m
resultsIn total, 475 male patients and 621 female patients were included in this study. At baseline, male patients had higher values for blood pressure, serum creatinine, urine protein and serum uric acid, as well as lower levels of eGFR. Further analysis indicated that tubular atrophy/interstitial fibrosis (T) lesions and vascular lesions were more frequent in male patients. During the follow-up period of 40.9 ± 24.2 months, kidney survival rates of male IgAN patients were remarkably lower than those of female patients. Using multivariate Cox regression analysis, male gender was identified as an independent risk factor for poor outcomes (β = 0.384, Wald = 4.290, Exp (β) = 1.47, p = 0.038), including hypertension, low eGFR, IgM deposition, arteriosclerosis lesions and T1-T2 lesions. However, male and female patients were characterized by different risk factors.
conclusionMale patients presented with more severe clinical and pathological changes than female patients. Renal survival rates of male patients were remarkably lower than those of female patients, and male gender was identified as an independent risk factor for poor outcomes.
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