Evidence map›Paper›PMID 32944872›Full record

ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2020

Analysis of airway microbiota in adults from a Brazilian cystic fibrosis center.

Cassiana Costa Ferreira Leite, Flavia Alvim Dutra de Freitas, Mônica de Cássia Firmida, Robson Souza Leão, Rodolpho Mattos Albano, Elizabeth Andrade Marques

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. [An updated review of the mechanism of fibrosis in acquired laryngotrachealstenosis].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2022
    Review
  4. Microbiome analysis of Cystic Fibrosis sputum presents higher sensitivity than the conventional bacterial culture.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Cassiana Costa Ferreira LeiteDepartment of Microbiology, Immunology and Parasitology, Faculty of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Flavia Alvim Dutra de FreitasDepartment of Microbiology, Immunology and Parasitology, Faculty of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Mônica de Cássia FirmidaDepartment of Chest Diseases, Faculty of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Robson Souza LeãoDepartment of Microbiology, Immunology and Parasitology, Faculty of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Rodolpho Mattos AlbanoDepartment of Biochemistry, Roberto Alcântara Gomes Biology Institute, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Elizabeth Andrade MarquesDepartment of Microbiology, Immunology and Parasitology, Faculty of Medical Sciences, State University of Rio de Janeiro, Rio de Janeiro, Brazil. marbe@uerj.br.ORCID http://orcid.org/0000-0003-3341-101X
Universidade do Estado do Rio de Janeiro · BR

Funding

Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/110.742/2013
6 · The paper itself

Abstract

The application of next-generation sequencing tools revealed that the cystic fibrosis respiratory tract is a polymicrobial environment. We have characterized the airway bacterial microbiota of five adult patients with cystic fibrosis during a 14-month period by 16S rRNA tag sequencing using the Illumina technology. Microbial diversity, estimated by the Shannon index, varied among patient samples collected throughout the follow-up period. The beta diversity analysis revealed that the composition of the airway microbiota was highly specific for each patient, showing little variation among the samples of each patient analyzed over time. The composition of the bacterial microbiota did not reveal any emerging pathogen predictor of pulmonary disease in cystic fibrosis or of its unfavorable clinical progress, except for unveiling the presence of anaerobic microorganisms, even without any established clinical association. Our results could potentialy help us to translate and develop strategies in response to the pathobiology of this disease, particularly because it represents an innovative approach for CF centers in Brazil.

Indexed as

MicrobiotaAdultBacteriaBrazilCystic FibrosisDNA, BacterialFemaleHigh-Throughput Nucleotide SequencingHumansMaleRespiratory SystemRNA, Ribosomal, 16SSequence Analysis, DNAYoung AdultDNA, BacterialRNA, Ribosomal, 16SAirway microbiotaCystic fibrosisNext-generation sequencing

Identifiers

PMID32944872
PMCPMC7688754
OpenAlexW3086703760

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.