ArticleInfection2021
Detection of SARS-CoV-2 in conjunctival secretions from patients without ocular symptoms.
Article in Infection, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 50 citations in OpenAlex.
- Cycle threshold values of SARS-CoV-2 RNA in conjunctival swabs and nasopharyngeal secretions: a comparative study from a tertiary care center in India.International ophthalmology · 2024Article
- Challenges in natural product-based drug discovery assisted withRSC advances · 2023Review
- Incidence and clinical characteristic of ocular surface manifestation: an evaluation of conjunctival swab results in Corona Virus 2019 (COVID-19) patients in Jakarta, Indonesia.Journal of ophthalmic inflammation and infection · 2023Article
- An insight into the altered ophthalmic dynamics during the COVID-19 pandemic.Indian journal of ophthalmology · 2022Article
- Eye-Related COVID-19: A Bibliometric Analysis of the Scientific Production Indexed in Scopus.International journal of environmental research and public health · 2022Article
- Duration of SARS-CoV-2 RNA positivity from various specimens and clinical characteristics in patients with COVID-19: a systematic review and meta-analysis.Inflammation and regeneration · 2022Review
- Anterior pituitary, sex hormones, and keratoconus: Beyond traditional targets.Progress in retinal and eye research · 2022Article
- COVID-19 and the eye: alternative facts The 2022 Bowman Club, David L. Easty lecture.BMJ open ophthalmology · 2022Review
- Multiplex metal-detection based assay (MMDA) for COVID-19 diagnosis and identification of disease severity biomarkers.Chemical science · 2022Article
- Therapeutic potential of the MDM2 inhibitor Nutlin-3 in counteracting SARS-CoV-2 infection of the eye through p53 activation.Frontiers in medicine · 2022Review
- SARS-CoV-2 and its beta variant of concern infect human conjunctival epithelial cells and induce differential antiviral innate immune response.The ocular surface · 2022Article
- Lessons learned 1 year after SARS-CoV-2 emergence leading to COVID-19 pandemic.Emerging microbes & infections · 2021Review
- Conjunctival polymerase chain reactions in COVID-19 patients and its correlation with clinical and paraclinical indexes.Iranian journal of microbiology · 2021Article
- The estimated risk of SARS-CoV- 2 infection via cornea transplant in Canada.Cell and tissue banking · 2021Article
- COVID-19 case presented initially with keratoconjunctivitis: A case report.Annals of medicine and surgery (2012) · 2021Article
- Conjunctival carriage of SARS-CoV-2 using serial sampling: risk factors and protective factors.Canadian journal of ophthalmology. Journal canadien d'ophtalmologie · 2021Article
- Identifying compounds that prevent the binding of the SARS-CoV-2 S-protein to ACE2.Computers in biology and medicine · 2021Article
- Neurologic Manifestations of Severe Acute Respiratory Syndrome Coronavirus 2 Infection.Continuum (Minneapolis, Minn.) · 2021Review
- Comparative evaluation of a dual-target real-time RT-PCR assay for COVID-19 diagnosis and assessment of performance in pooled saliva and nasopharyngeal swab samples.Expert review of molecular diagnostics · 2021Article
- SARS-CoV-2 infects human adult donor eyes and hESC-derived ocular epithelium.Cell stem cell · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 6 institutions in 2 countries.
Funding
Abstract
purposeTo evaluate the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in conjunctival secretions from patients without ocular symptoms.
methodsConjunctival swabs were prospectively collected from laboratory-confirmed Coronavirus disease 2019 (COVID-19) patients without ocular symptoms for reverse transcription-polymerase chain reaction (RT-PCR) and viral culture.
resultsA total of 158 conjunctival swabs were obtained from 49 laboratory-confirmed COVID-19 patients. The median duration of illness when the first conjunctival swab was obtained was 10 days (range 2-27 days). Four conjunctival swabs from four different patients (4/49, 8.2%) were positive for SARS-CoV-2 RNA by RT-PCR. The Ct values ranged from 32.7 to 37.7 (mean 35.4). Viral cultures were negative for all four RT-PCR-positive conjunctival swabs.
conclusionConjunctival secretions of a minority of COVID-19 patients without ocular symptoms may contain relatively low levels of SARS-CoV-2 RNA, but their infectiousness remains undetermined. Appropriate infection control measures should be implemented during ophthalmological assessment of COVID-19 patients to prevent potential nosocomial transmission of SARS-CoV-2.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.