Evidence map›Paper›PMID 32944799›Full record

ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2020

Quercetin alleviates neonatal hypoxic-ischemic brain injury by inhibiting microglia-derived oxidative stress and TLR4-mediated inflammation.

Kai Le, Zhiping Song, Jie Deng, Xin Peng, Jun Zhang, Liang Wang, Lu Zhou, Haidi Bi, Zhengyu Liao, Zhen Feng

Abstract read
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In one paragraph

Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
13.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it, 80 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. [Berberine attenuates necrotizing enterocolitis-associated brain injury via the TLR4/MyD88/NF-κB/NLRP3 pathway].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026
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  13. Computational Analysis andCurrent medicinal chemistry · 2026
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  15. Pretreatment with oleuropein protects the neonatal brain from hypoxia-ischemia by inhibiting apoptosis and neuroinflammation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025
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  20. [Gastrodin improves microglia-mediated inflammatory response after hypoxic-ischemic brain damage in neonatal ratsNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Kai Le *Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanchang University, No. 17 Yongwaizheng Street, Nanchang, 330006, Jiangxi Province, China.
Zhiping Song *Department of Anesthesia, The First Affiliated Hospital of Nanchang University, No. 17 Yongwaizheng Street, Nanchang, 330006, Jiangxi Province, China.
Jie DengDepartment of Neonatology, The Affiliated Children's Hospital of Nanchang University, No. 122 Yangming Road, Nanchang, 330006, Jiangxi Province, China.
Xin PengDepartment of Otolaryngology, The Affiliated Children's Hospital of Nanchang University, No. 122 Yangming Road, Nanchang, 330006, Jiangxi Province, China.
Jun ZhangDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Nanchang University, No. 17 Yongwaizheng Street, Nanchang, 330006, Jiangxi Province, China.
Liang WangDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Nanchang University, No. 17 Yongwaizheng Street, Nanchang, 330006, Jiangxi Province, China.
Lu ZhouDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Nanchang University, No. 17 Yongwaizheng Street, Nanchang, 330006, Jiangxi Province, China.
Haidi BiDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Nanchang University, No. 17 Yongwaizheng Street, Nanchang, 330006, Jiangxi Province, China.
Zhengyu LiaoDepartment of Orthodontics, School of Stomatology, The Key Laboratory of Oral Biomedicine, Affiliated Stomatological Hospital of Nanchang University, No. 49 Fuzhou Road, Nanchang, 330006, Jiangxi Province, China. hello67@163.com.ORCID http://orcid.org/0000-0001-8684-7373
Zhen FengDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Nanchang University, No. 17 Yongwaizheng Street, Nanchang, 330006, Jiangxi Province, China. fengzhenly@sina.com.
Nanchang University · CN

Funding

National Natural Science Foundation of China 81760203
6 · The paper itself

Abstract

OBJECTIVE AND

designMicroglia stimulated by oxygen glucose deprivation (OGD) were treated with quercetin to investigate the effect on oxidative stress and the inflammatory response and to explore whether toll-like receptor 4 (TLR4) signaling was involved. In addition, the effect of quercetin on the neurological functions of neonatal mice with hypoxic-ischemic brain injury (HIBI) was examined. MATERIALS AND SUBJECTS: Mouse BV2 microglial cells and postnatal day 7 neonatal mice were used. TREATMENT: A predetermined concentration of quercetin was used in cell experiments. Quercetin was injected i.p. (50 mg/kg) at three time points after HI insult: 0, 24, and 48 h.

methodsCell viability assay, Western blotting, qRT-RCR, ELISA, HIBI model construction and behavioral tests.

resultsThis study first showed that quercetin protected BV2 cells from OGD-induced damage and reversed the changes in microglial oxidative stress-related molecules. Second, quercetin inhibited OGD-induced expression of inflammatory factors in BV2 cells and suppressed TLR4/MyD88/NF-κB signaling. Finally, quercetin was disclosed to be effective in mitigating cerebral infarct volume and cognitive and motor function deficits in HIBI mice.

conclusionThese results suggest that the neuroprotective effect of quercetin in HIBI mice is partially due to the inhibition of oxidative stress and TLR4-mediated inflammatory responses in activated microglia.

Indexed as

AnimalsAnimals, NewbornAntioxidantsBehavior, AnimalCell LineCerebral InfarctionHypoxia-Ischemia, BrainMiceMicrogliaMyeloid Differentiation Factor 88NF-kappa BOxidative StressQuercetinReactive Oxygen SpeciesSignal TransductionToll-Like Receptor 4AntioxidantsMyd88 protein, mouseMyeloid Differentiation Factor 88NF-kappa BQuercetinReactive Oxygen SpeciesTlr4 protein, mouseToll-Like Receptor 4Hypoxic-ischemic brain injuryMicrogliaOxidative stressQuercetinTLR4

Identifiers

PMID32944799
OpenAlexW3087121230

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.