ArticleDiseases of the esophagus : official journal of the International Society for Diseases of the Esophagus2021
Use of vasopressors during esophagectomy is not associated with increased risk of anastomotic leak.
Article in Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Perioperative Use of Vasoactive Agents in Patients Undergoing Gastrointestinal Surgery: A Protocol for a Scoping Review.Acta anaesthesiologica Scandinavica · 2026Article
- Intraoperative Hemodynamic Management During Esophagectomy and Implications for Postoperative Care.Journal of the American College of Surgeons · 2026Article
- Association between intraoperative hypotension and adverse clinical outcomes after esophagectomy for esophageal cancer: retrospective observational study.JA clinical reports · 2025Article
- Impact of fluid balance and opioid-sparing anesthesia within enchanced recovery pathway on postoperative morbidity after transthoracic esophagectomy for cancer.Frontiers in medicine · 2024Article
- Evolving Perspectives on Esophagectomy Care: Clinical Update.Anesthesiology · 2023Article
- Post-esophagectomy Anastomosis Leak: A 10-Year Experience at a Specialized Center for Cancer Surgeries in Pakistan.Cureus · 2023Article
- Is there a relationship between two different anesthetic methods and postoperative length of stay during radical resection of malignant esophageal tumors in China?: a retrospective cohort study.BMC anesthesiology · 2022Article
- Peri-operative approach to esophagectomy: a narrative review from the anesthesiological standpoint.Journal of thoracic disease · 2021Review
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Vasopressor use during esophagectomy has been reported to increase the risk of postoperative anastomotic leak and associated morbidity. We sought to assess the association between vasopressor use and fluid (crystalloid and colloid) administration and anastomotic leak following open esophagectomy. Patients who underwent open Ivor Lewis esophagectomy were identified from a prospective institutional database. The primary outcome was postoperative anastomotic leak (any grade) and analyzed using logistic regression models. Postoperative anastomotic leak developed in 52 of 327 consecutive patients (16%) and was not significantly associated with vasopressor use or fluid administered in either univariable or multivariable analyses. Increasing body mass index was the only significant characteristic of both univariable (P = 0.004) and multivariable analyses associated with anastomotic leak (odds ratio, 1.05; 95% confidence interval, 1.01-1.09; P = 0.007). Of the 52 patients that developed an anastomotic leak, 12 (23%) were grade 1, 21 (40%) were grade 2 and 19 (37%) were grade 3. In our cohort, only body mass index, and not intraoperative vasopressor use and fluid administration, was significantly associated with increased odds of postoperative anastomotic leak following open Ivor Lewis esophagectomy.
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