Evidence map›Paper›PMID 32944634›Full record

ArticleMolecular & cellular oncology2020

PathSTORM: a road to early cancer detection.

Kris Troy, Yang Liu, Sarah J Hainer

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular & cellular oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kris TroyDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0001-7093-662X
Yang LiuBiomedical Optical Imaging Laboratory, Departments of Medicine and Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0002-6388-9674
Sarah J HainerDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0003-0503-1183
University of Pittsburgh · US

Funding

Chromatin-mediated mechanisms of transcription regulation in ES cellsR35GM133732 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sarah Jane Hainer · 2019 to 2026
$3.5M
(PQC2)Nanoscale changes in 3D nuclear architecture during breast tumorigenesisR01CA185363 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LIU, YANG · 2014 to 2017
$1.3M
High-throughput super-resolution imaging of chromatin structures at different epigenetic statesR33CA225494 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LIU, YANG · 2018 to 2020
$1.1M
NCI NIH HHS R01 CA185363NCI NIH HHS R33 CA225494NIGMS NIH HHS R35 GM133732
6 · The paper itself

Abstract

Disruption of chromatin structure could enable early carcinogenesis by facilitating malignant transformation. Using stochastic optical reconstruction microscopy optimized for pathological tissue (PathSTORM), we uncovered a gradual decompaction of higher-order chromatin folding through progressive stages of carcinogenesis. We demonstrated potential detection of pre-cancerous genomic architecture not easily discernible by conventional pathology.

Indexed as

chromatinCUT&RUNdiagnosticsoncogenesisPathSTORM

Identifiers

PMID32944634
PMCPMC7469673
OpenAlexW3036622724

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.