ArticleAnesthesiology and pain medicine2020
Comparison of Intrathecal Injection of Fentanyl and Sufentanil on the Onset, Duration, and Quality of Analgesia in Labor: A Randomized, Double-Blind Clinical Trial.
Article in Anesthesiology and pain medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Efficacy and safety of midazolam compared to fentanyl as adjuvants to hyperbaric bupivacaine in spinal anesthesia: a systematic review and meta-analysis of randomized controlled trials.BMC anesthesiology · 2025Pooled it
- Neuraxial homeostasis-guided labor analgesia to reduce neurologic symptom and enhance maternal satisfaction: a randomized clinical trial.Journal of translational medicine · 2026Trial
- Impact of different sufentanil concentrations in epidural labor analgesia on maternal and neonatal outcomes: a propensity score-matched cohort study.BMC pregnancy and childbirth · 2026Article
- Dual-opioid spinal anaesthesia in enhanced recovery after caesarean section: effects on postoperative opioid requirement and maternal recovery.Journal of anesthesia, analgesia and critical care · 2026Article
- Dexamethasone as a sufentanil adjuvant effects on labor pain management and neonatal safety.Annals of medicine and surgery (2012) · 2025Article
- A Systematic Review of Contemporary and Emerging Analgesia Techniques for Natural Labor-Patient-Centered Approaches and Technological Advances.Journal of clinical medicine · 2025Review
- Safety and Efficiency of Low-Dose Spinal Analgesia Compared to Epidural Analgesia in Treatment of Pain during Labour: A Case Control Study.Journal of clinical medicine · 2023Article
- Post-cesarean Delivery Analgesia Using Spinal Anesthesia: Ropivacaine-Fentanyl vs. Ropivacaine-Sufentanil.Anesthesiology and pain medicine · 2023Article
- Article
- The Influence of Analgesic Modalities on Postoperative Cancer Recurrence.Anesthesiology and pain medicine · 2022Review
- Anesthetic Conversion of Preexisting Labor Epidural Analgesia for Emergency Cesarean Section and Efficacy of Levobupivacaine with or Without Magnesium Sulphate: A Prospective Randomized Study.Anesthesiology and pain medicine · 2022Article
- Full Opioid Agonists and Tramadol: Pharmacological and Clinical Considerations.Anesthesiology and pain medicine · 2021Review
- Comparison of Spinal Versus Epidural Analgesia for Vaginal Delivery: A Randomized Double Blinded Clinical Trial.Anesthesiology and pain medicine · 2021Article
- Comparative Study of Effect of Spinal Anesthesia in Sitting and Lateral Positions on the Onset Time of Sensory Block and Hemodynamic Condition in Cesarean Section: A Randomized Clinical Trial.Anesthesiology and pain medicine · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLabor pain is a severe pain, and intrathecal opioid injection is one of the analgesia methods to reduce it.
objectivesWe assessed the effects of intrathecal Fentanyl and Sufentanil on the onset, duration, and quality of analgesia for labor analgesia.
methodsIn this double-blind, randomized clinical trial, 54 healthy nulliparous women 18 - 45 years in the active phase of labor who were requesting labor analgesia were enrolled in two groups fentanyl (F) and sufentanil (S). Patients received 75 µg fentanyl or 7.5 µg sufentanil intrathecally in the fentanyl group (n = 27) and the sufentanil group (n = 27), respectively. Pain relief, onset, duration of analgesia, hemodynamic parameters, patients' satisfaction, and neonatal Apgar score were assessed in this study. Data were analyzed by using SPSS16.
resultsThere were no significant differences between the groups in terms of demographic and hemodynamic parameters. The onset time of analgesia was 5.6 ± 4.3 and 3.6 ± 2.1 minutes, in the sufentanil and fentanyl groups, respectively (P = 0.037). The duration of analgesia was higher in patients who received sufentanil than those who received fentanyl (113 ± 45 vs. 103 ± 22 minutes (P = 0.629)). The pain score in the Fentanyl group was significantly lower at 5, 10, and 15 minutes after spinal analgesia (P < 0.05). The sedation score at 1 and 5 minutes was significantly higher in the fentanyl group than the sufentanil group (P < 0.05). The frequency and severity of pruritus and satisfaction rate in the fentanyl group were significantly higher than the sufentanil group.
conclusionsIntrathecal fentanyl and sufentanil have a similar analgesic effect on labor. Fentanyl is associated with a faster onset of analgesia and more satisfaction, while sufentanil has longer analgesia.
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