ArticlePeerJ2020
Mimicking prophage induction in the body: induction in the lab with pH gradients.
Article in PeerJ, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Viral Lifecycle Dynamics and Spatial Structure Explain Why Accessory Genes Are Associated With Temperate Phages.Genome biology and evolution · 2026Article
- Prophage: agent provocateur?Archives of microbiology · 2026Review
- Diverse Temperate Coliphages of the Urinary Tract.Viruses · 2026Article
- Phage Therapy for Urinary Tract Infections: Progress and Challenges Ahead.International urogynecology journal · 2025Review
- Gut phages and their interactions with bacterial and mammalian hosts.Journal of bacteriology · 2025Review
- Prophage-DB: a comprehensive database to explore diversity, distribution, and ecology of prophages.Environmental microbiome · 2025Article
- Dietary Effects on the Gut Phageome.International journal of molecular sciences · 2024Review
- Prophage-DB: A comprehensive database to explore diversity, distribution, and ecology of prophages.bioRxiv : the preprint server for biology · 2024Article
- Viral diversity and host associations in microbial electrolysis cells.ISME communications · 2024Article
- Article
- Article
- Coliphages of the human urinary microbiota.PloS one · 2023Article
- Bacteriophage therapy in aquaculture: current status and future challenges.Folia microbiologica · 2022Review
- Bacteriophage-Bacteria Interactions in the Gut: From Invertebrates to Mammals.Annual review of virology · 2021Review
- Interactions of Bacteriophages with Animal and Human Organisms-Safety Issues in the Light of Phage Therapy.International journal of molecular sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The majority of bacteria within the human body are lysogens, often harboring multiple bacteriophage sequences (prophages) within their genomes. While several different types of environmental stresses can trigger or induce prophages to enter into the lytic cycle, they have yet to be fully explored and understood in the human microbiota. In the laboratory, the most common induction method is the DNA damaging chemical Mitomycin C. Although pH has been listed in the literature as an induction method, it is not widely used. Here, we detail a protocol for prophage induction by culture under different pH conditions. We explored the effects of pH on prophage induction in bacterial isolates from the bladder, where the pH is well documented to vary significantly between individuals as well as between healthy individuals and individuals with urinary tract symptoms or disease. Using this protocol, we successfully induced phages from seven bladder
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.