Evidence map›Paper›PMID 32944391›Full record

ReviewCancer biology & medicine2020

MiR-135a biogenesis and regulation in malignancy: a new hope for cancer research and therapy.

Zhe Cao, Jiangdong Qiu, Gang Yang, Yueze Liu, Wenhao Luo, Lei You, Lianfang Zheng, Taiping Zhang

Abstract readReview
In one paragraph

Review in Cancer biology & medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The regulatory role ofOncology research · 2025
    Pooled it
  2. Review
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  4. Article
  5. Article
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  7. Review
  8. Therapeutic Applications of Poly-miRNAs and miRNA Sponges.International journal of molecular sciences · 2025
    Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhe CaoDepartment of General Surgery.
Jiangdong QiuDepartment of General Surgery.
Gang YangDepartment of General Surgery.
Yueze LiuDepartment of General Surgery.
Wenhao LuoDepartment of General Surgery.
Lei YouDepartment of General Surgery.
Lianfang ZhengDepartment of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Taiping ZhangDepartment of General Surgery.ORCID 0000-0003-1689-6908

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) are evolutionarily conserved small non-coding RNAs that affect posttranscriptional regulation by binding to the 3'-untranslated region of target messenger RNAs. MiR-135a is a critical miRNA that regulates gene expression, and many studies have focused on its function in cancer research. MiR-135a is dysregulated in various cancers and regulates cancer cell proliferation and invasion

Indexed as

Gene Expression Regulation, Neoplastic3' Untranslated RegionsBiomarkers, TumorCell ProliferationDrug DiscoveryEpithelial-Mesenchymal TransitionHumansJanus Kinase 2MicroRNAsNeoplasmsSignal TransductionSTAT3 Transcription Factor3' Untranslated RegionsBiomarkers, TumorJanus Kinase 2MicroRNAsMIRN135 microRNA, humanSTAT3 Transcription FactorBiomarkercancerchemoresistanceepithelial-mesenchymal transitionmiR-135atherapeutics

Identifiers

PMID32944391
PMCPMC7476096

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.