ArticleBMC nutrition2020
Effect of milk fat-based infant formulae on stool fatty acid soaps and calcium excretion in healthy term infants: two double-blind randomised cross-over trials.
Article in BMC nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Skin care interventions in infants for preventing eczema and food allergy.The Cochrane database of systematic reviews · 2022Pooled it
- Effects of feeding infant formula rich in sn-2 palmitate for 6 months on fecal saponified fatty acids, calcium and stool characteristics: a cluster-randomized controlled trial.Nutrition journal · 2025Trial
- The Effect of Partly Replacing Vegetable Fat with Bovine Milk Fat in Infant Formula on Postprandial Lipid and Energy Metabolism: A Proof-of-principle Study in Healthy Young Male Adults.Molecular nutrition & food research · 2021Trial
- Human Milk as a Model for Next-Generation Infant Formula: Opportunities and Challenges.Advances in nutrition (Bethesda, Md.) · 2026Review
- Observational
- Progress in triacylglycerol isomer detection in milk lipids.Food chemistry: X · 2024Review
- Observational
- A cross-sectional study on stool- and gastrointestinal-related outcomes of Mexican infants consuming different formulae.BMC pediatrics · 2023Observational
- Effect of bovine milk fat-based infant formulae on microbiota, metabolites and stool parameters in healthy term infants in a randomized, crossover, placebo-controlled trial.BMC nutrition · 2022Article
- A Scoping Review of Clinical Studies in Infants Fed Formulas Containing Palm Oil or Palm Olein and Sn-2 Palmitate.The Journal of nutrition · 2021Article
- The effect of calcium palmitate on bacteria associated with infant gut microbiota.MicrobiologyOpen · 2021Article
- Growth and Neurodevelopment to 18 Months in Infant With Varying sn-2 Palmitate Levels in Formula: An Observational Study.Pediatrics international : official journal of the Japan Pediatric SocietyObservational
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPalmitic acid (PA) is predominantly esterified at the SN-2 position of triacylglycerols in human milk. PA at the SN-2 position is more efficiently absorbed and results in reduced formation of PA soaps, as well as reduced fatty acid (FA) and calcium malabsorption. Bovine milk fat (MF), a natural source of SN-2-palmitate, was used in the fat blend of infant formulae (IF) in the current study to investigate its effect on stool fatty acid soaps, calcium excretion and stool characteristics.
methodsTwo double-blind, randomised cross-over trials (CS1, CS2) were conducted in parallel with healthy term, formula-fed infants aged 9-14 weeks. After a two-week run-in period, infants in CS1 (
resultsMF-based groups showed no significant difference in PA in stools compared to VF group, although reduced stool PA soaps (CS1: 111.28 ± 18.33 vs. 220.25 ± 29.35 mg/g dry weight,
conclusionsWhile the use of bovine MF in IF did not affect PA concentrations in stool, lower excretion of palmitate soaps, total FA soaps and calcium was seen in healthy term infants. 50MF formula also showed improved stool consistency. The use of MF in IF could be an interesting approach to improve gut comfort and stool characteristics in infants, warranting further research.
trial registrationNetherlands Trial Registry Identifier: NTR6702. Date registered: December 01, 2017.
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