Evidence map›Paper›PMID 32944183›Full record

ArticleJournal of extracellular vesicles2020

Dendritic cell derived exosomes loaded with immunoregulatory cargo reprogram local immune responses and inhibit degenerative bone disease

Mahmoud Elashiry, Mohamed M Elashiry, Ranya Elsayed, Mythily Rajendran, Carol Auersvald, Rana Zeitoun, Mohammad H Rashid, Roxan Ara, Mohamed M Meghil, Yutao Liu and 7 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of extracellular vesicles, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 107 citations in OpenAlex.

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  7. Effects of exosomes from different origins on osteoclasts.Journal of orthopaedic surgery and research · 2025
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  16. Extracellular vesicles in bone aging: therapeutic strategies and applications.Extracellular vesicles and circulating nucleic acids · 2025
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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 3 countries.

Mahmoud ElashiryDepartment of Periodontics, Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia at Augusta University, Augusta, GA, USA.ORCID https://orcid.org/0000-0001-7077-2725
Mohamed M ElashiryDepartment of Periodontics, Dental College of Georgia at Augusta University, GA, USA, Department of Endodontics, Faculty of Dentistry, Ain Shams University, Cairo, Egypt.
Ranya ElsayedDepartment of Periodontics, Dental College of Georgia at Augusta University, GA, USA.
Mythily RajendranDepartment of Periodontics, Dental College of Georgia at Augusta University, GA, USA.
Carol AuersvaldDepartment of Periodontics, Dental College of Georgia at Augusta University, GA, USA.
Rana ZeitounDepartment of Oral Biology and Diagnostic Sciences, Dental College of Georgia at Augusta University, Department of Fixed Prosthodontics, Faculty of Dentistry, Ain Shams University, Cairo, Egypt.
Mohammad H RashidDepartment of Biochemistry & Molecular Biology, Georgia Cancer Center, Augusta, GA, USA.
Roxan AraDepartment of Biochemistry & Molecular Biology, Georgia Cancer Center, Augusta, GA, USA.
Mohamed M MeghilDepartment of Periodontics, Department of Oral Biology and Diagnostic Sciences, Dental College of Georgia at Augusta University, Augusta, GA, USA.
Yutao LiuDepartment of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, GA, USA.
Ali S ArbabDepartment of Biochemistry & Molecular Biology, Georgia Cancer Center, Augusta, GA, USA.
Roger M ArceDepartment of Periodontics and Oral Hygiene, School of Dentistry, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Mark HamrickDepartment of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, GA, USA.
Mohammed ElsalantyDepartment of Periodontics, Dental College of Georgia at Augusta University, GA, USA.
Marshall BrendanDepartment of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, GA, USA.
Rafal PacholczykGeorgia Cancer Center, Augusta, GA, USA.
Christopher W CutlerDepartment of Periodontics, Dental College of Georgia at Augusta University, GA, USA.ORCID https://orcid.org/0000-0003-4396-4072
Augusta University · USNational Cancer Center of Georgia · GEAin Shams University · EGThe University of Texas Health Science Center at Houston · USWestern University of Health Sciences · US

Funding

Long Noncoding RNA lncLOXL1 and Exfoliation Syndrome.R21EY028671 · NEI · AUGUSTA UNIVERSITY · PI LIU, YUTAO · 2018 to 2019
$467k
6 · The paper itself

Abstract

Chronic bone degenerative diseases represent a major threat to the health and well-being of the population, particularly those with advanced age. This study isolated exosomes (EXO), natural nano-particles, from dendritic cells, the "directors" of the immune response, to examine the immunobiology of DC EXO in mice, and their ability to reprogram immune cells responsible for experimental alveolar bone loss

Indexed as

alveolar Bone lossexosomesinflammation(MeSH): Dendritic Cellsperiodontitis

Identifiers

PMID32944183
PMCPMC7480413
OpenAlexW3048286913

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.