Evidence map›Paper›PMID 32944079›Full record

ArticleMolecular cytogenetics2020

A new childhood ALL case with an extremely complex karyotype and acute spontaneous tumor lysis syndrome.

Abdulsamad Wafa, Rami A Jarjour, Doaa Alolabi, Thomas Liehr, Othman Hamdan, Joana B Melo, Isabel M Carreira, Moneeb A K Othman, Walid Al-Achkar

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In one paragraph

Article in Molecular cytogenetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

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0 citing papers in PubMed, 1 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Abdulsamad WafaDepartment of Molecular Biology and Biotechnology, Human Genetics Division, Atomic Energy Commission, Damascus, Syria.
Rami A JarjourDepartment of Molecular Biology and Biotechnology, Human Genetics Division, Atomic Energy Commission, Damascus, Syria.
Doaa AlolabiDepartment of Hematology, Damascus Children University Hospital, Ministry of High Education, Damascus, Syria.
Thomas LiehrJena University Hospital, Institute of Human Genetics, Jena, Germany.
Othman HamdanDepartment of Hematology, Damascus Children University Hospital, Ministry of High Education, Damascus, Syria.
Joana B MeloCytogenetics and Genomics Laboratory, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Isabel M CarreiraCytogenetics and Genomics Laboratory, Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
Moneeb A K OthmanJena University Hospital, Institute of Human Genetics, Jena, Germany.
Walid Al-AchkarDepartment of Molecular Biology and Biotechnology, Human Genetics Division, Atomic Energy Commission, Damascus, Syria.
Atomic Energy Commission of Syria · SYJena University Hospital · DEUniversity of Coimbra · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundB cell precursor acute lymphoblastic leukemia (B-ALL) is the most common malignancy of childhood, with, after corresponding treatment, an overall complete remission rate of 90%. Approximately 75% of B-ALL cases harbor recurrent abnormalities, including so-called complex karyotypes (CK). Tumor lysis syndrome (TLS) is a metabolic abnormality which may arise during cancer therapy and also, extremely rarely, as spontaneous TLS before initiation of chemotherapy in patients with ALL. CASE PRESENTATION: Here we report a 9-year-old male, diagnosed with a de novo pre-B-ALL according to the WHO classification. Cytogenetic, molecular cytogenetic approaches and array comparative genomic hybridization analyses revealed a unique CK involving five chromosomes. It included four yet unreported chromosomal aberrations: a der(11)t(7;11)(p22.1;q24.2), a der(18)t(7;18)(q21.3;p11.22), del(11)(q24.2q25) and dup(18)(q11.1q23). Unfortunately, the patient died 3 months after the initial diagnosis.

conclusionsTo the best of our knowledge, a comparable childhood ALL case was not previously reported. Thus, the combination of the here seen chromosomal aberrations in childhood primary ALL seems to indicate for an extremely adverse prognosis.

Indexed as

Acute lymphoblastic leukemia (ALL)Array comparative genomic hybridization (aCGH)Complex karyotype (CK)Molecular cytogeneticsPrognostic factorsTumor lysis syndrome (TLS)

Identifiers

PMID32944079
PMCPMC7488544
OpenAlexW3086972472

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