Evidence map›Paper›PMID 32944060›Full record

ArticleJournal of occupational medicine and toxicology (London, England)2020

Basal cell carcinoma risk and solar UV exposure in occupationally relevant anatomic sites: do histological subtype, tumor localization and Fitzpatrick phototype play a role? A population-based case-control study.

A Bauer, E Haufe, L Heinrich, A Seidler, H J Schulze, P Elsner, H Drexler, S Letzel, S M John, M Fartasch and 16 more

Open access · goldAbstract read
In one paragraph

Article in Journal of occupational medicine and toxicology (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Photoprotection in occupational dermatology.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2023
    Article
  8. Article
  9. Review
  10. [The UV Protection Alliance in Germany-Purpose and goals].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2022
    Review
  11. Article
  12. Article
  13. [Update on occupational skin cancer-basal cell carcinoma and solar UV exposure].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2021
    Review
  14. [Photocarcinogenesis-molecular mechanisms and practical relevance].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2021
    Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 10 institutions in 1 country.

A Bauer *Department of Dermatology, University AllergyCentre, Medical Faculty Carl Gustav Carus, Technical University Dresden, Fetscherstr 74, D-01307 Dresden, Germany.ORCID 0000-0002-4411-3088
E Haufe *Centre of Evidence-based Healthcare, University Hospital and Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany.
L HeinrichCentre of Evidence-based Healthcare, University Hospital and Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany.
A SeidlerInstitute and Policlinic for Occupational and Social Medicine, Faculty of Medicine Carl Gustav Carus, Dresden, Germany.
H J SchulzeDepartment of Dermatology, Dermatological Radiotherapy and Dermatohistopathology, Special Clinics Hornheide, Münster, Germany.
P ElsnerDepartment of Dermatology, University Hospital Jena, Jena, Germany.
H DrexlerInstitute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
S LetzelInstitute of Occupational, Social and Environmental Medicine, University Medical Centre, Johannes-Gutenberg University Mainz, Mainz, Germany.
S M JohnDepartment of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück and Institute of Interdisciplinary Dermatological Prevention and Rehabilitation (iDerm) at the University of Osnabrück, Osnabrück, Germany.
M FartaschInstitute for Prevention and Occupational Medicine of the German Social Accident Insurance (DGUV), Institute of Ruhr University Bochum (IPA), Bochum, Germany.
T BrüningInstitute for Prevention and Occupational Medicine of the German Social Accident Insurance (DGUV), Institute of Ruhr University Bochum (IPA), Bochum, Germany.
S Dugas-BreitDepartment of Dermatology, Dermatological Radiotherapy and Dermatohistopathology, Special Clinics Hornheide, Münster, Germany.
M GinaDepartment of Dermatology, University Hospital Jena, Jena, Germany.
W WeistenhöferInstitute and Outpatient Clinic of Occupational, Social and Environmental Medicine, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.
K BachmannDepartment of Clinical Social Medicine, Occupational and Environmental Dermatology, University of Heidelberg, Heidelberg, Germany.
I BruhnDepartment of Dermatology, University AllergyCentre, Medical Faculty Carl Gustav Carus, Technical University Dresden, Fetscherstr 74, D-01307 Dresden, Germany.
B M LangDepartment of Dermatology, University Medical Centre, Johannes-Gutenberg University Mainz, Mainz, Germany.
R BransDepartment of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück and Institute of Interdisciplinary Dermatological Prevention and Rehabilitation (iDerm) at the University of Osnabrück, Osnabrück, Germany.
J P AllamDepartment of Dermatology and Allergology, Christine Kühne Center for Allergy Research and Education, University of Bonn, Bonn, Germany.
W GrobeDepartment of Dermatology and Allergology, Christine Kühne Center for Allergy Research and Education, University of Bonn, Bonn, Germany.
S WesterhausenDepartment of Radiation, Institute of Occupational Health and Safety of the German Social Accident Insurance (DGUV), Sankt Augustin, Germany.
P KnuschkeDepartment of Dermatology, Experimental Photobiology, Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany.
M WittlichDepartment of Radiation, Institute of Occupational Health and Safety of the German Social Accident Insurance (DGUV), Sankt Augustin, Germany.
T L DiepgenDepartment of Clinical Social Medicine, Occupational and Environmental Dermatology, University of Heidelberg, Heidelberg, Germany.
J SchmittCentre of Evidence-based Healthcare, University Hospital and Medical Faculty Carl Gustav Carus, Technical University Dresden, Dresden, Germany.
FB181 study group
University Hospital Carl Gustav Carus · DEFachklinik Hornheide · DEFriedrich-Alexander-Universität Erlangen-Nürnberg · DEHeidelberg University · DEInstitute for Prevention and Occupational Medicine · DEInstitut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung · DEJena University Hospital · DEJohannes Gutenberg University Mainz · DEOsnabrück University · DEUniversity of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA two-fold risk increase to develop basal cell carcinoma was seen in outdoor workers exposed to high solar UV radiation compared to controls. However, there is an ongoing discussion whether histopathological subtype, tumor localization and Fitzpatrick phototype may influence the risk estimates.

objectivesTo evaluate the influence of histological subtype, tumor localization and Fitzpatrick phototype on the risk to develop basal cell carcinoma in highly UV-exposed cases and controls compared to those with moderate or low solar UV exposure.

methodsSix hundred forty-three participants suffering from incident basal cell carcinoma in commonly sun-exposed anatomic sites (capillitium, face, lip, neck, dorsum of the hands, forearms outside, décolleté) of a population-based, case-control, multicenter study performed from 2013 to 2015 in Germany were matched to controls without skin cancer. Multivariate logistic regression analysis was conducted stratified for histological subtype, phototype 1/2 and 3/4. Dose-response curves adjusted for age, age

resultsParticipants with high versus no (OR 2.08; 95% CI 1.24-3.50;

conclusionThe risk to develop basal cell carcinoma in highly occupationally UV-exposed skin was doubled consistently, independent of histological subtype, tumor localization and Fitzpatrick phototype.

Indexed as

Basal cell carcinomaFitzpatrick phototypeHistological subtypeLocalizationOccupationOutdoor workSolar UV exposure

Identifiers

PMID32944060
PMCPMC7488106
OpenAlexW3084402805

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.