Evidence map›Paper›PMID 32944014›Full record

ArticleEngineering in life sciences2020

Microflow system promotes acetaminophen crystal nucleation.

Akari Nishigaki, Mihoko Maruyama, Munenori Numata, Chisako Kanzaki, Shun-Ichi Tanaka, Hiroshi Y Yoshikawa, Masayuki Imanishi, Masashi Yoshimura, Yusuke Mori, Kazufumi Takano

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Engineering in life sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Akari NishigakiDepartment of Biomolecular Chemistry Kyoto Prefectural University Kyoto Japan.
Mihoko MaruyamaDepartment of Biomolecular Chemistry Kyoto Prefectural University Kyoto Japan.
Munenori NumataDepartment of Biomolecular Chemistry Kyoto Prefectural University Kyoto Japan.
Chisako KanzakiDepartment of Biomolecular Chemistry Kyoto Prefectural University Kyoto Japan.
Shun-Ichi TanakaDepartment of Biomolecular Chemistry Kyoto Prefectural University Kyoto Japan.
Hiroshi Y YoshikawaDepartment of Chemistry Saitama University Saitama Japan.
Masayuki ImanishiGraduate School of Engineering Osaka University Suita Japan.
Masashi YoshimuraInstitute of Laser Engineering Osaka University Suita Japan.
Yusuke MoriGraduate School of Engineering Osaka University Suita Japan.
Kazufumi TakanoDepartment of Biomolecular Chemistry Kyoto Prefectural University Kyoto Japan.ORCID https://orcid.org/0000-0002-7548-7314

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is known that interfaces have various impacts on crystallization from a solution. Here, we describe crystallization of acetaminophen using a microflow channel, in which two liquids meet and form a liquid-liquid interface due to laminar flow, resulting in uniform mixing of solvents on the molecular scale. In the anti-solvent method, the microflow mixing promoted the crystallization more than bulk mixing. Furthermore, increased flow rate encouraged crystal formation, and a metastable form appeared under a certain flow condition. This means that interface management by the microchannel could be a beneficial tool for crystallization and polymorph control.

Indexed as

anti‐solvent methodlaminar flowliquid–liquid interfacemetastable formpolymorph control

Identifiers

PMID32944014
PMCPMC7481770

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.