ArticleInfection and drug resistance2020
Emergence of NDM-5-Producing Carbapenem-Resistant
Article in Infection and drug resistance, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Clinical value of metagenomic next-generation sequencing in screening oropharyngeal colonization in patients undergoing allogeneic hematopoietic stem cell transplantation: a prospective observational study.Microbiology spectrum · 2025Observational
- Hypervirulent Carbapenem-resistantInfection and drug resistance · 2025Review
- Recombination Drives Evolution of Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 11 KL47 to KL64 in China.Microbiology spectrum · 2023Article
- Molecular Epidemiology of Carbapenem ResistantInfection and drug resistance · 2023Article
- Clonal Spread of Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 11 in Chinese Pediatric Patients.Microbiology spectrum · 2022Article
- Genomic Analysis of Multidrug-Resistant Hypervirulent (Hypermucoviscous)Antibiotics (Basel, Switzerland) · 2022Article
- Molecular insights into novel environmental strains ofFrontiers in public health · 2022Article
- Mortality Risk Factors and Prognostic Analysis of Patients with Multi-Drug ResistantInfection and drug resistance · 2022Article
- Characterization of the First Carbapenem-Resistant Pseudomonas aeruginosa Clinical Isolate HarboringAntimicrobial agents and chemotherapy · 2021Article
- Epidemiology of patients with central nervous system infections, mainly neurosurgical patients: a retrospective study from 2012 to 2019 in a teaching hospital in China.BMC infectious diseases · 2021Article
- Neonatal Sepsis: The Impact of Carbapenem-Resistant and HypervirulentFrontiers in medicine · 2021Review
- Co-Production of NDM-1, CTX-M-9 Family and mcr-1 in aInfection and drug resistance · 2021Article
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10 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeTo characterize the clinical, resistance, and virulence features of carbapenem-resistant MATERIALS AND
methodsTwelve strains were collected and investigated these isolates for their antimicrobial susceptibility and molecular features. Resistance mechanisms, virulence-associated genes, multilocus sequence typing (MLST), and serotypes were detected by PCR and sequencing. Next general sequencing (NGS) was carried out to determine the features of carbapenem resistance and virulence. The synergistic activity of tigecycline-imipenem (TGC+IPM), tigecycline-meropenem (TGC+MEM), and tigecycline-aztreonam (TGC+ATM) combinations were performed by microdilution checkerboard method.
resultsEleven CRKP and one hvKP strains were collected. All strains showed highly sensitive rates to tigecycline (TGC) and amikacin (AMK). NDM (33.3%, 4/12) was the main resistance mechanism and MLST assigned 3 of them to ST11. CTX-M-producing (n = 1) and KPC-2-producing (n = 1) isolates belonged to ST147 and ST11, respectively. The MICs of ATM and quinolones in NDM-1 CRKP and NDM-5 CRKP strains were different. The serotype of the majority strains was KL22KL137 (58.3%, 7/12), hvKP stain belonged to K64. CRKP strains harbored plasmid-mediated quinolone resistance genes (oqxA, oqxB, qnrS, qnrB), β-lactams (
conclusionWe first identified the NDM-5-producing ST690 CRKP and SIM-producing ST1764 hvKP strains in Shanxi province. Tigecycline-carbapenem combinations were available treatments for CRKP.
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