Evidence map›Paper›PMID 32943850›Full record

ArticlePatient preference and adherence2020

Level of Adherence and Associated Factors Among HIV-Infected Patients on Antiretroviral Therapy in Northern Ethiopia: Retrospective Analysis.

Abraham Aregay Desta, Kibriti Mehari Kidane, Ataklti Gebretsadik Woldegebriel, Kiros Fenta Ajemu, Asfawosen Aregay Berhe, Degnesh Negash Zgita, Letebrhan Weldemhret Teweldemedhn, Lemlem Legesse Woldegebriel, Nega Mamo Bezabih, Tewolde Wubayehu Woldearegay

Open access · goldAbstract read
In one paragraph

Article in Patient preference and adherence, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
0.2field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Abraham Aregay DestaTigray Health Research Institute, Mekelle, Tigray, Ethiopia.ORCID 0000-0002-1505-7451
Kibriti Mehari KidaneTigray Health Research Institute, Mekelle, Tigray, Ethiopia.
Ataklti Gebretsadik WoldegebrielTigray Health Research Institute, Mekelle, Tigray, Ethiopia.
Kiros Fenta AjemuTigray Health Research Institute, Mekelle, Tigray, Ethiopia.ORCID 0000-0002-7608-0284
Asfawosen Aregay BerheTigray Health Research Institute, Mekelle, Tigray, Ethiopia.
Degnesh Negash ZgitaTigray Health Research Institute, Mekelle, Tigray, Ethiopia.
Letebrhan Weldemhret TeweldemedhnTigray Health Research Institute, Mekelle, Tigray, Ethiopia.ORCID 0000-0002-6951-5702
Lemlem Legesse WoldegebrielTigray Health Research Institute, Mekelle, Tigray, Ethiopia.
Nega Mamo BezabihTigray Health Research Institute, Mekelle, Tigray, Ethiopia.
Tewolde Wubayehu WoldearegayTigray Health Research Institute, Mekelle, Tigray, Ethiopia.
Mekelle University · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPoor adherence to ART increases viremia, which leads to disease progression and transmission of drug-resistant HIV strains. This study aimed to assess the level of ART adherence and associated factors among adolescents and adult patients enrolled in ART care in Northern Ethiopia.

methodsA retrospective analysis was conducted among 19,525 patients from April 2015 to March 2019. Data verification and filtration were done in Excel 2013 before exporting to STATA 14.0. Ordinal logistic regression was used to analyze the data.

resultsAbout 94.84%, 95% CI (94.52%, 95.14%) of the study subjects were in good adherence. However, about 1.46%, 95% CI (1.30%, 1.64%) and 3.70%, 95% CI (3.44%, 3.97%) of them had poor and fair adherence respectively. In the adjusted analysis, being male (AOR = 0.75; 95% CI: 0.0.65, 0.87), patients from general hospitals (AOR = 0.52; 95% CI: 0.39, 0.69), WHO staging IV (AOR = 0.57; 95% CI: 0.41, 0.81) and non-suppressed viral load (VL) status (AOR = 0.54; 95% CI: 0.47, 0.63) were negatively associated with good adherence. Whereas, age of 50+ years old (AOR = 1.68; 95% CI: 1.13, 2.50), recent CD4 count of 200-499 (AOR = 1.45; 95% CI: 1.21, 1.74) and recent CD4 count of 500 and above (AOR = 1.84; 95% CI: 1.47, 2.32) were positively associated with good ART drug adherence.

conclusionThere was a higher level of adherence compared to the previous studies conducted in Ethiopia. Being male, patients from general hospitals, WHO staging II, II and IV and non-suppressed VL status were negatively associated with good adherence. Whereas, older ages, recent CD4 count of 200-499 and ≥500 CD4 count were positively associated with good ART drug adherence. The health system should recognize a higher need of younger age groups and males to design targeted counseling and support to encourage consistently high levels of adherence for a better ART treatment outcome.

Indexed as

adherence and complianceantiretroviral therapyretreatment

Identifiers

PMID32943850
PMCPMC7481295
OpenAlexW3082757563

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.