ArticleScientific reports2020
Early origin and global colonisation of foot-and-mouth disease virus.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- An Overview of Epidemiological Tools That Support the Progress of Foot-and-Mouth Disease Control in Southeast Asia.Pathogens (Basel, Switzerland) · 2026Review
- Article
- Prevalence and Serotype Distribution of Foot and Mouth Disease (FMD) Virus in Asian Countries: A Systematic Review and Meta-Analysis.Veterinary medicine international · 2026Review
- Serological Detection of O-Type and A-Type Antibodies Against Foot-and-Mouth Disease in Tongliao City, 2021-2022.Veterinary medicine international · 2026Article
- Recombination hotspots and genetic variability in foot-and-mouth disease virus genomes: a comparative genomic and phylogeographic analysis.Archives of virology · 2025Article
- Epidemiology and economics of foot-and-mouth disease: current understanding and knowledge gaps.Veterinary research · 2025Review
- Transoceanic pathogen transfer in the age of sail and steam.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A review of foot-and-mouth disease in Ethiopia: epidemiological aspects, economic implications, and control strategies.Virology journal · 2023Review
- Conserved antigen structures and antibody-driven variations on foot-and-mouth disease virus serotype A revealed by bovine neutralizing monoclonal antibodies.PLoS pathogens · 2023Article
- Molecular detection, genetic diversity, and phylogenetic analysis of foot-and-mouth disease virus (FMDV) type O in Iran during 2015-2016.Iranian journal of veterinary research · 2023Article
- Epidemiology of foot-and-mouth disease outbreaks in Thailand from 2011 to 2018.Transboundary and emerging diseases · 2022Article
- Foot-and-Mouth Disease Virus Interserotypic Recombination in Superinfected Carrier Cattle.Pathogens (Basel, Switzerland) · 2022Article
- Measuring How Recombination Re-shapes the Evolutionary History of PRRSV-2: A Genome-Based Phylodynamic Analysis of the Emergence of a Novel PRRSV-2 Variant.Frontiers in veterinary science · 2022Article
- Validation of Pretreatment Methods for the In-Process Quantification of Foot-and-Mouth Disease Vaccine Antigens.Vaccines · 2021Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
In this study, we compiled 84-year worth (1934-2017) of genomic and epidemiological data of foot-and-mouth disease virus (FMDV), and performed comprehensive analyses to determine its early origin and transmission route. We found that recombination is a key feature of FMDV, and that the genomic regions coding for structural and non-structural proteins have markedly different evolutionary histories, and evolve at different rates. Despite all of these differences, analyses of both structural and non-structural protein coding regions consistently suggested that the most recent common ancestor of FMDV could be dated back to the Middle Age, ~ 200 to 300 years earlier than previously thought. The ancestors of the Euro-Asiatic and SAT strains could be dated back to the mid-seventeenth century, and to the mid-fifteenth to mid-sixteenth century, respectively. Our results implicated Mediterranean counties as an early geographical origin of FMDV before spreading to Europe and subsequently to Asia and South America.
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