Evidence map›Paper›PMID 32943574›Full record

ArticleGenes & development2020

The DNA replication fork suppresses CMG unloading from chromatin before termination.

Emily Low, Gheorghe Chistol, Manal S Zaher, Olga V Kochenova, Johannes C Walter

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 53 citations in OpenAlex.

  1. Review
  2. Reconstitution of genome remodeling usingFrontiers in cell and developmental biology · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Emily Low *Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blavatnik Institute, Boston, Massachusetts 02115, USA.
Gheorghe Chistol *Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blavatnik Institute, Boston, Massachusetts 02115, USA.
Manal S ZaherDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blavatnik Institute, Boston, Massachusetts 02115, USA.
Olga V KochenovaDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blavatnik Institute, Boston, Massachusetts 02115, USA.
Johannes C WalterDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Blavatnik Institute, Boston, Massachusetts 02115, USA.
Boston VA Research Institute · USHarvard University · USHoward Hughes Medical Institute · US

Funding

The mechanism of vertebrate DNA replication terminationR01GM080676 · NIGMS · HARVARD MEDICAL SCHOOL · PI WALTER, JOHANNES · 2007 to 2019
$3.7M
Ubiquitylation and Helicase Unloading in Eukaryotic DNA Replication TerminationF31GM122277 · NIGMS · HARVARD MEDICAL SCHOOL · PI LOW, EMILY · 2017 to 2018
$69k
Howard Hughes Medical InstituteNIGMS NIH HHS F31 GM122277NIGMS NIH HHS R01 GM080676
6 · The paper itself

Abstract

When converging replication forks meet during replication termination, the CMG (Cdc45-MCM2-7-GINS) helicase is polyubiquitylated by CRL2

Indexed as

DNA ReplicationAnimalsCell Cycle ProteinsChromatinChromosomal Proteins, Non-HistoneDNAMinichromosome Maintenance ProteinsRecombinant ProteinsUbiquitinationXenopus laevisXenopus ProteinsCdc45 protein, XenopusCell Cycle ProteinsChromatinChromosomal Proteins, Non-HistoneDNAMinichromosome Maintenance ProteinsRecombinant ProteinsXenopus ProteinsCMGCRL2Lrr1DNA replicationreplication terminationsingle-molecule imagingubiquitylation

Identifiers

PMID32943574
PMCPMC7608748
OpenAlexW3087402143

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.