ArticleEuropean respiratory review : an official journal of the European Respiratory Society2020
Respiratory muscle senescence in ageing and chronic lung diseases.
Article in European respiratory review : an official journal of the European Respiratory Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
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- Airway Extracellular Copper Concentrations Increase with Age and Are Associated with Oxidative Stress Independent of Disease State: A Case-Control Study Including Patients with Asthma and COPD.Antioxidants (Basel, Switzerland) · 2025Article
- Inverted L-shape association between a body shape index and peak expiratory flow among middle-aged and older adults: findings from the China Health and Retirement Longitudinal Study (CHARLS).Lipids in health and disease · 2025Article
- Respiratory and peripheral muscle ultrasound, including shear-wave elastography, for sarcopenia screening in COPD.Frontiers in nutrition · 2025Article
- Ultrasound Evaluation of Diaphragmatic and Intercostal Muscle Function as an Indicator of COPD Severity: A Prospective Cross-Sectional Study.International journal of chronic obstructive pulmonary disease · 2025Article
- Lung function and the risk of frailty in the European population: a mendelian randomization study.European journal of medical research · 2024Article
- Respiratory Muscle Function in Older Adults with Chronic Respiratory Diseases after Pulmonary Rehabilitation in Subterranean Salt Chambers.Journal of clinical medicine · 2023Article
- Mapping Genetics and Epigenetics to Explore the Pathways beyond the Correlated Ageing Phenotype.Genes · 2022Article
- New insights of epigenetics in vascular and cellular senescence.Journal of translational internal medicine · 2021Review
- Dynamic Aging: Channeled Through Microenvironment.Frontiers in physiology · 2021Review
- CTCF Mediates Replicative Senescence Through POLD1.Frontiers in cell and developmental biology · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ageing is a progressive condition that usually leads to the loss of physiological properties. This process is also present in respiratory muscles, which are affected by both senescent changes occurring in the whole organism and those that are more specific for muscles. The mechanisms of the latter changes include oxidative stress, decrease in neurotrophic factors and DNA abnormalities. Ageing normally coexists with comorbidities, including respiratory diseases, which further deteriorate the structure and function of respiratory muscles. In this context, changes intrinsic to ageing become enhanced by more specific factors such as the impairment in lung mechanics and gas exchange, exacerbations and hypoxia. Hypoxia in particular has a direct effect on muscles, mainly through the expression of inducible factors (hypoxic-inducible factor), and can result in oxidative stress and changes in DNA, decrease in mitochondrial biogenesis and defects in the tissue repair mechanisms. Intense exercise can also cause damage in respiratory muscles of elderly respiratory patients, but this can be followed by tissue repair and remodelling. However, ageing interferes with muscle repair by tampering with the function of satellite cells, mainly due to oxidative stress, DNA damage and epigenetic mechanisms. In addition to the normal process of ageing, stress-induced premature senescence can also occur, involving changes in the expression of multiple genes but without modifications in telomere length.
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