Trial reportBMC medicine2020
Colon capsule endoscopy versus CT colonography in FIT-positive colorectal cancer screening subjects: a prospective randomised trial-the VICOCA study.
Trial report in BMC medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02081742 (COMPARATIVE STUDY OF THE EFFICACY OF TWO NON-INVASIVE IMAGING TECHNIQUES IN POPULATION SCREENING FOR COLORECTAL CANCER), which is not on this map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparative study of the efficacy of two non-invasive imaging techniques in population screening for colorectal cancer (crc): colon capsule and virtual colonoscopy
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Second-generation capsule endoscopy for the detection of colorectal polyps: An updated systematic review and comparative meta-analysis of prospective studies.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026Pooled it
- Systematic review and meta-analysis of colon capsule endoscopy accuracy for colorectal cancer screening. An alternative during the Covid-19 pandemic?Journal of medical screening · 2022Pooled it
- Re-investigation rate following colon capsule endoscopy stratified by faecal haemoglobin concentration in a screening population.Therapeutic advances in gastroenterology · 2026Article
- Colon Capsule Endoscopy as a Promising Diagnostic Tool in Colorectal Cancer: A Systematic Review and Network Meta-Analysis.Diagnostics (Basel, Switzerland) · 2025Review
- Colon capsule endoscopy is an effective filter test for colonic polyp surveillance.World journal of gastrointestinal endoscopy · 2025Article
- Multicentre Study of 10,369 Symptomatic Patients Comparing the Diagnostic Accuracy of Colon Capsule Endoscopy, Colonoscopy and CT Colonography.Alimentary pharmacology & therapeutics · 2025Article
- Development and validation of computer-aided detection for colorectal neoplasms using deep learning incorporated with computed tomography colonography.BMC gastroenterology · 2025Article
- Towards full integration of explainable artificial intelligence in colon capsule endoscopy's pathway.Scientific reports · 2025Article
- Conference Report: The FutuRE oF MinimalLy InvasivE GI and Capsule DiagnosTics (REFLECT) Nyborg, Denmark, October 2023.Diagnostics (Basel, Switzerland) · 2024Article
- Potential of Fecal Carcinoembryonic Antigen for Noninvasive Detection of Colorectal Cancer: A Systematic Review.Cancers · 2023Review
- An evaluation of a novel bowel preparation regimen and its effect on the utility of colon capsule endoscopy: a prospective cohort study with historical controls.Techniques in coloproctology · 2023Article
- Colon Capsule Endoscopy - Shining the Light through the Colon.Current gastroenterology reports · 2023Review
- Clinical utility of colon capsule endoscopy: a moving target?Therapeutic advances in gastroenterology · 2023Review
- Advances in colon capsule endoscopy: a review of current applications and challenges.Frontiers in gastroenterology (Lausanne, Switzerland) · 2023Review
- Low Colon Capsule Endoscopy (CCE) False Negative Rate for Polyps Excluding Reader Error.Diagnostics (Basel, Switzerland) · 2022Article
- Colon Capsule Endoscopy in the Diagnosis of Colon Polyps: Who Needs a Colonoscopy?Diagnostics (Basel, Switzerland) · 2022Review
- Edge artificial intelligence wireless video capsule endoscopy.Scientific reports · 2022Article
- A colorectal cancer missed by colon capsule endoscopy: a case report.BMC gastroenterology · 2022Article
- ScotCap - A large observational cohort study.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2022Observational
- Follow-up of small and diminutive colonic polyps-How to balance the risks in the COVID-19 era.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundColon capsule endoscopy (CCE) and CT colonography (CTC) are minimally invasive techniques for colorectal cancer (CRC) screening. Our objective is to compare CCE and CTC for the identification of patients with colorectal neoplasia among participants in a CRC screening programme with positive faecal immunochemical test (FIT). Primary outcome was to compare the performance of CCE and CTC in detecting patients with neoplastic lesions.
methodsThe VICOCA study is a prospective, single-centre, randomised trial conducted from March 2014 to May 2016; 662 individuals were invited and 349 were randomised to CCE or CTC before colonoscopy. Endoscopists were blinded to the results of CCE and CTC.
resultsThree hundred forty-nine individuals were included: 173 in the CCE group and 176 in the CTC group. Two hundred ninety individuals agreed to participate: 147 in the CCE group and 143 in the CTC group. In the intention-to-screen analysis, sensitivity, specificity and positive and negative predictive values for the identification of individuals with colorectal neoplasia were 98.1%, 76.6%, 93.7% and 92.0% in the CCE group and 64.9%, 95.7%, 96.8% and 57.7% in the CTC group. In terms of detecting significant neoplastic lesions, the sensitivity of CCE and CTC was 96.1% and 79.3%, respectively. Detection rate for advanced colorectal neoplasm was higher in the CCE group than in the CTC group (100% and 93.1%, respectively; RR = 1.07; p = 0.08). Both CCE and CTC identified all patients with cancer. CCE detected more patients with any lesion than CTC (98.6% and 81.0%, respectively; RR = 1.22; p = 0.002).
conclusionAlthough both techniques seem to be similar in detecting patients with advanced colorectal neoplasms, CCE is more sensitive for the detection of any neoplastic lesion.
trial registrationClinicalTrials.gov Identifier: NCT02081742 . Registered: September 16, 2013.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.