SynthesisBMC medical informatics and decision making2020
Meta-analysis of contrast-enhanced ultrasound and contrast-enhanced harmonic endoscopic ultrasound for the diagnosis of gallbladder malignancy.
Synthesis in BMC medical informatics and decision making, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 11 citations in OpenAlex.
- Approach to gallbladder polyps in pediatric patients.World journal of clinical pediatrics · 2025Review
- Risk stratification of gallbladder masses by machine learning-based ultrasound radiomics models: a prospective and multi-institutional study.European radiology · 2023Article
- Gallbladder polyp in children - a rare finding during ultrasound examination.Journal of ultrasonography · 2022Article
- A Novel Endoscopic Ultrasonography Imaging Technique for Depicting Microcirculation in Pancreatobiliary Lesions without the Need for Contrast-Enhancement: A Prospective Exploratory Study.Diagnostics (Basel, Switzerland) · 2021Article
- The Role of Endoscopic Ultrasound in the Diagnosis of Gallbladder Lesions.Diagnostics (Basel, Switzerland) · 2021Review
Corrections and comments
- Retraction · 2022-06-07Concerns/Issues about Data · Unreliable Results and/or Conclusions ·
- Retracted
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe diagnosis between benign and malignant gallbladder lesions is sometimes difficult. The objective of this study is to assess whether contrast-enhanced ultrasound (CEUS) and contrast-enhanced harmonic endoscopic ultrasound (CH-EUS) can be an accurate method for detecting gallbladder malignancy and to determine which imaging signs can be indicative of malignancy.
methodsA study search of PubMed, Elsevier, and Sciencedirect was performed in May 2019. The pooled sensitivity, specificity, diagnostic odds ratio (DOR), and summary receiver operating characteristic (SROC) curve were used to examine the accuracy of CEUS and CH-EUS.
resultsTwenty-one studies were included in the meta-analysis. The pooled sensitivities of CEUS and CH-EUS were 0.81 (0.75-0.86) and 0.92 (0.86-0.95); the specificities were 0.94 (0.90-0.96) and 0.89 (0.69-0. 97); the DORs were 64 (32-127) and 89 (22-354); and the area under the SROC curves were 0.90 (0.87-0.92) and 0.92 (0.90-0.94). On CEUS, the diagnostic criterion for gallbladder malignancy according to four features were analyzed. Sensitivity and specificity were 0.75 (0.65-0.83) and 0.98 (0.85-1.00) for integrity of gallbladder wall; 0.69 (0.55-0.81) and 0.89 (0.77-0.95) for heterogeneous enhancement; 0.81 (0.71-0.88) and 0.88 (0.76-0.94) for irregular vessels; and 0.81 (0.66-0.91) and 0.75 (0.59-0.86) for washout time within 28 s. On CH-EUS, heterogeneous enhancement could be indicative of malignant lesions with a sensitivity of 0.94 (0.85-0.97); and the specificity was 0.92 (0.71-0.98).
conclusionsCEUS and CH-EUS are promising and reliable imaging modalities with a high sensitivity and specificity for the diagnosis of gallbladder malignancy. CH-EUS might be more sensitive than CEUS with a higher sensitivity. In addition, irregular tralesional vessels and washout time within 28 s on CEUS and heterogeneous enhancement on CH-EUS are indicative of malignancy. However, larger scale and well-designed studies are warranted to verify our results.
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